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Ethylphenylhydantoin

Known as: nirvanol, (+-)-3-Ethyl-5-phenylhydantoin, 5-phenyl-5-ethylhydantoin 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

AnticonvulsantsHydantoin derivative anticonvulsantMephenytoin
EthotoinPeganoneanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
(+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.
Highly potent and selective CYP2C19 inhibitors are not currently available. In the present study, N-3-benzyl derivatives of… 
Highly Cited
2002
Highly Cited
2002
Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism.
Cytochrome P450 2B6 is a genetically polymorphic enzyme that is important in the metabolism of a number of clinically used drugs… 
Highly Cited
1998
Highly Cited
1998
Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6.
We tested the ability of human liver microsomes (HLMs) and recombinant human cytochrome P450 (CYP or P450) isoforms to catalyze… 
Highly Cited
1996
Highly Cited
1996
Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.
In vitro methods were used to identify the cytochrome P450 (CYP) enzyme(s) involved in S-mephenytoin N-demethylation. S… 
Highly Cited
1988
Highly Cited
1988
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis…
Male F344/NCr rats, 6 wk old, were fed 500 ppm of phenobarbital (PB) or equimolar doses of either 5-ethyl-5-phenylhydantoin (EPH… 
Highly Cited
1985
Highly Cited
1985
Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography.
Highly Cited
1984
Highly Cited
1984
Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians
The frequency of genetically deficient hydroxylation of mephenytoin (M‐defect) was studied in 83 healthy Caucasians living in… 
1982
1982
5-ethyl-5-phenylhydantoin N-glucuronide, the major urinary metabolite of 5-ethyl-5-phenylhydantoin (Nirvanol) in the dog.
A water-soluble metabolite, isolated from the urine of dogs given (S)-5-ethyl-5-phenylhydantoin [(S)-EPH], has been identified as… 
1979
1979
Clinical pharmacology of mephenytoin and ethotoin
Effective prescribing of anticonvulsants requires foreknowledge of baseline pharmacokinetic data. Little such information is… 
1975
1975
Flash-heater ethylation of some antiepileptic drugs.
We describe a modification of the MacGee method [Anal. Chem. 42, 421 (1970)] for rapid determination of phenytoin… 
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