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Background:Metabolism and clearance of racemic methadone are stereoselective and highly variable, yet the mechanism remains… Expand SummaryInherited deficiency in mephenytoin hydroxylation was observed in a family study. It is important that the propositus was… Expand Highly potent and selective CYP2C19 inhibitors are not currently available. In the present study, N-3-benzyl derivatives of… Expand Cytochrome P450 2B6 is a genetically polymorphic enzyme that is important in the metabolism of a number of clinically used drugs… Expand The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing… Expand Previous studies in this laboratory have determined the lack of specificity of several antibody and substrate probes of CYP2B6… Expand The teratogenicity of many xenobiotics is thought to depend at least in part upon their bioactivation by embryonic cytochromes… Expand In vitro methods were used to identify the cytochrome P450 (CYP) enzyme(s) involved in S-mephenytoin N-demethylation. S… Expand A high-performance liquid chromatographic method for the simultaneous determination of carbamazepine, CGP 10 000 (a common… Expand Deficient aromatic hydroxylation of S‐mephenytoin was observed in an index subject during a kinetic study of stereoselective… Expand