Hydantoin derivative anticonvulsant

G-quadruplex is a four-stranded G-rich DNA structure that is highly susceptible to oxidation. Despite the important roles that G… Expand

Accumulation of oxidative DNA damage has been proposed as a potential cause of age-related cognitive decline. The major pathway… Expand

Human DNA glycosylase NEIL1 exhibits a superior ability to remove oxidized guanine lesions guanidinohydantoin (Gh) and… Expand

Oxidation of guanine (G) and 8-oxoguanine (OG) with a wide variety of oxidants yields the hydantoin lesions, guanidinohydantoin… Expand

Phenytoin (DPH) is a clinically useful sodium (Na) channel blocker with efficacy against partial and generalized seizures. We… Expand

Abstract. Cloning and sequencing of a 7.1 kb DNA fragment from Agrobacterium sp IP I-671 revealed seven open reading frames (ORFs… Expand

A superfamily of cyclic amidohydrolases, including dihydropyrimidinase, allantoinase, hydantoinase, and dihydroorotase, all of… Expand

In Arthrobacter aurescens DSM 3747 three enzymes are involved in the complete conversion of slowly racemizing 5'-monosubstituted… Expand

DNA fragments containing the genes involved in the conversion of 5-substituted hydantoins to their corresponding L-amino acids… Expand

Trigeminal neuralgia (tic douloureux) is characterized by brief paroxysms of pain limited to the facial distribution of the… Expand