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Hydantoin derivative anticonvulsant

Known as: Hydantoin 
 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (11)

AllantoinDantroleneDihydanEthotoin
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Broader (4)

AnticonvulsantsHydantoinsImidazolesimidazoledione

Papers overview

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2015
2015
Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity.
DNA topoisomerase I is a potential chemotherapeutic target. Here, we designed and synthesized a library comprising of hydantoin… Expand
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2015
2015
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
G-quadruplex is a four-stranded G-rich DNA structure that is highly susceptible to oxidation. Despite the important roles that G… Expand
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Highly Cited
2012
Highly Cited
2012
Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells.
Accumulation of oxidative DNA damage has been proposed as a potential cause of age-related cognitive decline. The major pathway… Expand
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Highly Cited
2010
Highly Cited
2010
Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts.
Human DNA glycosylase NEIL1 exhibits a superior ability to remove oxidized guanine lesions guanidinohydantoin (Gh) and… Expand
2001
2001
Cloning and characterization of genes from Agrobacterium sp. IP I-671 involved in hydantoin degradation
Abstract. Cloning and sequencing of a 7.1 kb DNA fragment from Agrobacterium sp IP I-671 revealed seven open reading frames (ORFs… Expand
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2001
2001
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The… Expand
2000
2000
Hydantoin racemase from Arthrobacter aurescens DSM 3747: heterologous expression, purification and characterization.
In Arthrobacter aurescens DSM 3747 three enzymes are involved in the complete conversion of slowly racemizing 5'-monosubstituted… Expand
2000
2000
Functional expression and characterization of the two cyclic amidohydrolase enzymes, allantoinase and a novel phenylhydantoinase, from Escherichia coli.
A superfamily of cyclic amidohydrolases, including dihydropyrimidinase, allantoinase, hydantoinase, and dihydroorotase, all of… Expand
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1992
1992
Identification and sequencing of a gene encoding a hydantoin racemase from the native plasmid of Pseudomonas sp. strain NS671.
DNA fragments containing the genes involved in the conversion of 5-substituted hydantoins to their corresponding L-amino acids… Expand
Highly Cited
1959
Highly Cited
1959
THE MECHANISM OF THE PAIN IN TRIGEMINAL NEURALGIA
Trigeminal neuralgia (tic douloureux) is characterized by brief paroxysms of pain limited to the facial distribution of the… Expand
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