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Hydantoin derivative anticonvulsant
Known as:
Hydantoin
National Institutes of Health
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Related topics
Related topics
15 relations
Narrower (11)
Allantoin
Dantrolene
Dihydan
Ethotoin
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Broader (4)
Anticonvulsants
Hydantoins
Imidazoles
imidazoledione
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity.
Papiya Majumdar
,
Chandramohan Bathula
,
+6 authors
B. B. Das
European journal of medicinal chemistry
2015
Corpus ID: 207244963
DNA topoisomerase I is a potential chemotherapeutic target. Here, we designed and synthesized a library comprising of hydantoin…
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2015
2015
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
Jia Zhou
,
A. Fleming
,
A. Averill
,
C. Burrows
,
S. Wallace
Nucleic acids research
2015
Corpus ID: 54578104
G-quadruplex is a four-stranded G-rich DNA structure that is highly susceptible to oxidation. Despite the important roles that G…
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Highly Cited
2012
Highly Cited
2012
Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells.
C. E. Regnell
,
G. Hildrestrand
,
+8 authors
L. Bergersen
Cell reports
2012
Corpus ID: 22714696
Accumulation of oxidative DNA damage has been proposed as a potential cause of age-related cognitive decline. The major pathway…
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Highly Cited
2010
Highly Cited
2010
Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts.
Xiaobei Zhao
,
N. Krishnamurthy
,
C. Burrows
,
S. David
Biochemistry
2010
Corpus ID: 38324799
Human DNA glycosylase NEIL1 exhibits a superior ability to remove oxidized guanine lesions guanidinohydantoin (Gh) and…
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2001
2001
Cloning and characterization of genes from Agrobacterium sp. IP I-671 involved in hydantoin degradation
M. Hils
,
P. Münch
,
J. Altenbuchner
,
C. Syldatk
,
R. Mattes
Applied Microbiology and Biotechnology
2001
Corpus ID: 25769162
Abstract. Cloning and sequencing of a 7.1 kb DNA fragment from Agrobacterium sp IP I-671 revealed seven open reading frames (ORFs…
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2001
2001
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
D. Kim
,
L. Wang
,
+19 authors
E. Emini
Bioorganic & medicinal chemistry letters
2001
Corpus ID: 32271264
A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The…
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2000
2000
Hydantoin racemase from Arthrobacter aurescens DSM 3747: heterologous expression, purification and characterization.
A. Wiese
,
M. Pietzsch
,
C. Syldatk
,
R. Mattes
,
J. Altenbuchner
Journal of biotechnology
2000
Corpus ID: 39737639
In Arthrobacter aurescens DSM 3747 three enzymes are involved in the complete conversion of slowly racemizing 5'-monosubstituted…
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2000
2000
Functional expression and characterization of the two cyclic amidohydrolase enzymes, allantoinase and a novel phenylhydantoinase, from Escherichia coli.
G. J. Kim
,
D. E. Lee
,
H. S. Kim
Journal of bacteriology
2000
Corpus ID: 9949595
A superfamily of cyclic amidohydrolases, including dihydropyrimidinase, allantoinase, hydantoinase, and dihydroorotase, all of…
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1992
1992
Identification and sequencing of a gene encoding a hydantoin racemase from the native plasmid of Pseudomonas sp. strain NS671.
K. Watabe
,
T. Ishikawa
,
Y. Mukohara
,
H. Nakamura
Journal of bacteriology
1992
Corpus ID: 6236125
DNA fragments containing the genes involved in the conversion of 5-substituted hydantoins to their corresponding L-amino acids…
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Highly Cited
1959
Highly Cited
1959
THE MECHANISM OF THE PAIN IN TRIGEMINAL NEURALGIA
E. Kugelberg
,
U. Lindblom
Journal of neurology, neurosurgery, and…
1959
Corpus ID: 26774733
Trigeminal neuralgia (tic douloureux) is characterized by brief paroxysms of pain limited to the facial distribution of the…
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