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Mephenytoin

Known as: Methyl Phenetoin, Methoin, Mephenytoin [Chemical/Ingredient] 
A heterocyclic organic compound with anticonvulsant property. Although the mechanism of action is not well established, mephenytoin potentially… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVE Many drugs, including proton pump inhibitors and certain antidepressants, are metabolized by the… Expand
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Highly Cited
2004
Highly Cited
2004
SummaryInherited deficiency in mephenytoin hydroxylation was observed in a family study. It is important that the propositus was… Expand
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Highly Cited
2004
Highly Cited
2004
SummaryEuropean data on the polymorphic metabolism of debrisoquine, sparteine, dextromethorphan and mephenytoin have been… Expand
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Review
2001
Review
2001
The human CYP2Cs are an important subfamily of P450 enzymes that metabolize approximately 20% of clinically used drugs. There are… Expand
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Highly Cited
1998
Highly Cited
1998
The 4'-hydroxylation of the S-enantiomer of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans. This… Expand
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Highly Cited
1997
Highly Cited
1997
The 4'-hydroxylation of S-mephenytoin is polymorphic in man. The poor metabolizer (PM) phenotype exhibits a lower frequency in… Expand
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Highly Cited
1995
Highly Cited
1995
A single oral dose of omeprazole (20 mg) was given orally to 160 healthy Caucasian Swedish subjects and tested as a probe for… Expand
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Highly Cited
1994
Highly Cited
1994
The metabolism of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans, with the poor metabolizer trait… Expand
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Highly Cited
1993
Highly Cited
1993
The relationship between the metabolism of the selective serotonin reuptake inhibitor citalopram and the sparteine and… Expand
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Highly Cited
1985
Highly Cited
1985
Interethnic differences in debrisoquin and mephenytoin hydroxylation have been compared between normal white (n = 183) and… Expand
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