Mephenytoin

Known as: Methyl Phenetoin, Methoin, Mephenytoin [Chemical/Ingredient] 
A heterocyclic organic compound with anticonvulsant property. Although the mechanism of action is not well established, mephenytoin potentially… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
0204019462016

Papers overview

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Highly Cited
2004
Highly Cited
2004
The human clearance of proton pump inhibitors (PPIs) of the substituted benzimidazole class is conducted primarily by the hepatic… (More)
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Highly Cited
1997
Highly Cited
1997
The 4'-hydroxylation of S-mephenytoin is polymorphic in man. The poor metabolizer (PM) phenotype exhibits a lower frequency in… (More)
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Highly Cited
1996
Highly Cited
1996
OBJECTIVE To assess the genotype pattern of S-mephenytoin 4'-hydroxylation in an extended Japanese population. METHODS One… (More)
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Highly Cited
1995
Highly Cited
1995
A single oral dose of omeprazole (20 mg) was given orally to 160 healthy Caucasian Swedish subjects and tested as a probe for… (More)
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Highly Cited
1994
Highly Cited
1994
The metabolism of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans, with the poor metabolizer trait… (More)
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Highly Cited
1994
Highly Cited
1994
The present study assesses the role of members of the human CYP2C subfamily in the 4'-hydroxylation of (S)-mephenytoin. When… (More)
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Highly Cited
1993
Highly Cited
1993
In an effort to identify and characterize minor forms of human liver cytochrome P450, immunoblot analyses of microsome samples… (More)
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Highly Cited
1990
Highly Cited
1990
European data on the polymorphic metabolism of debrisoquine, sparteine, dextromethorphan and mephenytoin have been collected. No… (More)
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Highly Cited
1985
Highly Cited
1985
Interethnic differences in debrisoquin and mephenytoin hydroxylation have been compared between normal white (n = 183) and… (More)
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Highly Cited
1984
Highly Cited
1984
Inherited deficiency in mephenytoin hydroxylation was observed in a family study. It is important that the propositus was of the… (More)
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