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Eplivanserin Hemifumarate

Known as: (4-((1E,3Z)-3-((2-(Dimethylamino)Ethoxy)Imino)-3-(2-Fluorophenyl)Prop-1- Enyl)Phenol)(2E)-2-Butenedioate (2:1), 2-Propen-1-One, 1-(2-Fluorophenyl)-3-(4-Hydroxyphenyl)-, O-(2- (Dimethylamino)Ethyl)Oxime, (1z,2e)-, (2e)-2-Butenedioate (2:1), SR46349B 
National Institutes of Health

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Eplivanserin

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SR 46349B

Papers overview

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2011
2011
Involvement of 5-HT2A receptors in MDMA reinforcement and cue-induced reinstatement of MDMA-seeking behaviour.
The serotonergic system appears crucial for (±)-3,4-methylenedioxymethamphetamine (MDMA) reinforcing properties. Current evidence… 
2011
2011
The role of serotonin-2 (5-HT2) and dopamine receptors in the behavioral actions of the 5-HT2A/2C agonist, DOI, and putative 5-HT2C inverse agonist, SR46349B
RationaleAtypical antipsychotic efficacy is often attributed to actions at serotonin-2 (5-HT2) and dopamine receptors, indicating… 
2009
2009
Inhibition of Monoamine Oxidases Desensitizes 5-HT1A Autoreceptors and Allows Nicotine to Induce a Neurochemical and Behavioral Sensitization
Although nicotine is generally considered to be the main compound responsible for addictive properties of tobacco, experimental… 
2007
2007
Paradoxical constitutive behavioral sensitization to amphetamine in mice lacking 5-HT2A receptors
RationaleAlthough locomotor response to d-amphetamine is considered as mediated by an increased release of dopamine in the… 
2007
2007
Opportunities for isotopic labelling via phase‐tagged synthesis with organogermanium linkers
Strategies for the use of germanium-based linkers for the phase-tagged synthesis of isotopically labelled intermediates are… 
Highly Cited
2006
Highly Cited
2006
Behavioral sensitization to amphetamine results from an uncoupling between noradrenergic and serotonergic neurons.
In rodents, drugs of abuse induce locomotor hyperactivity, and repeating injections enhances this response. This effect, called… 
2005
2005
Clozapine increases cutaneous blood flow and reduces sympathetic cutaneous vasomotor alerting responses (SCVARs) in rats: comparison with effects of haloperidol
RationaleClozapine inhibits sympathetic outflow to the cutaneous vascular bed. Clozapine reverses hyperthermia and cutaneous… 
2004
2004
Role of serotonin 2A receptors in the D-amphetamine-induced release of dopamine: comparison with previous data on alpha1b-adrenergic receptors.
D-amphetamine is known to induce an increase in dopamine release in subcortical structures, thus inducing locomotor hyperactivity… 
2002
2002
Regulation of striatal neuropeptide mRNAs: Effects of the 5‐HT2 antagonist SR46349B in adult rats with a neonatal 6‐hydroxydopamine lesion
The intrastriatal injection of 6‐hydroxydopamine (6‐OHDA) in newborn rats produces a marked striatal dopamine (DA) depletion… 
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