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Involvement of the Extracellular Signal-Regulated Kinase Cascade for Cocaine-Rewarding Properties
TLDR
Results reveal a new mechanism to explain behavioral responses of cocaine related to its addictive properties, and suggest that the ERK intracellular signaling cascade is also involved in the prime burst of gene expression underlying long-term behavioral changes induced by cocaine. Expand
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene
TLDR
Investigation of the behavioural effects of morphine reveals that a lack of μ receptors abolishes the analgesic effect of morphine, as well as place-preference activity and physical dependence, and concludes that the µ-opioid-receptor gene product is a mandatory component of the opioid system for morphine action. Expand
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.
TLDR
The Oprd1-encoded receptor, which has been proposed to be a promising target for the clinical management of pain, should also be considered in the treatment of drug addiction and other mood-related disorders. Expand
Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration
TLDR
The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence. Expand
Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory
TLDR
The results reveal an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction. Expand
Role of different brain structures in the expression of the physical morphine withdrawal syndrome.
TLDR
The results suggest that the locus coeruleus, and secondarily the periaqueductal gray matter, play an important role in the precipitation of the physical signs of opiate withdrawal, mainly in the expression of its motor component. Expand
Involvement of the endocannabinoid system in drug addiction
TLDR
Clinical trials have suggested that the CB(1) cannabinoid antagonist rimonabant can cause smoking cessation, Thus, CB( 1) cannabinoid antagonists could represent a new generation of compounds to treat drug addiction. Expand
Behavioural and biochemical evidence for interactions between Δ9‐tetrahydrocannabinol and nicotine
TLDR
Results clearly demonstrate the existence of a functional interaction between THC and nicotine, which could play an important role in the development of addictive processes. Expand
Differential Role of Anandamide and 2-Arachidonoylglycerol in Memory and Anxiety-like Responses
TLDR
It is shown that anandamide is a central component in the modulation of memory consolidation, whereas 2-arachidonoylglycerol is not involved in this process and the interest of cannabinoid receptor 2 is revealed as a novel target for the treatment of anxiety-related disorders. Expand
Involvement of CB1 cannabinoid receptors in emotional behaviour
TLDR
Findings demonstrate that endogenous cannabinoids through the activation of CB1 receptors are implicated in the control of emotional behaviour and participate in the physiological processes of learning and memory. Expand
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