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Involvement of the Extracellular Signal-Regulated Kinase Cascade for Cocaine-Rewarding Properties
A central feature of drugs of abuse is to induce gene expression in discrete brain structures that are critically involved in behavioral responses related to addictive processes. AlthoughExpand
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Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration
The present study was designed to explore the relationship between the cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. The acute administration of SR141716A, aExpand
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Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory
Extracellular signal-regulated kinases (ERK1 and 2) are synaptic signaling components necessary for several forms of learning. In mice lacking ERK1, we observe a dramatic enhancement ofExpand
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Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling
Cognitive impairment is one of the most important negative consequences associated with cannabis consumption. We found that CB1 cannabinoid receptor (CB1R) activation transiently modulated theExpand
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Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid Receptors
Repeated THC administration produces motivational and somatic adaptive changes leading to dependence in rodents. To investigate the molecular basis for cannabinoid dependence and its possibleExpand
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Involvement of the opioid system in the anxiolytic-like effects induced by Δ9-tetrahydrocannabinol
AbstractRationale. Recent studies have shown that several pharmacological actions induced by cannabinoids, including antinociception and reward, involve the participation of the endogenous opioidExpand
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Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice
The involvement of cannabinoid CB1 receptors in morphine and cocaine motivational effects was investigated using CB1 knockout mice. For this purpose, we evaluated the rewarding effects in the placeExpand
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Δ9‐tetrahydrocannabinol‐induced MAPK/ERK and Elk‐1 activation in vivo depends on dopaminergic transmission
It is now well established that central effects of Δ9‐tetrahydrocannabinol (THC), the main psychoactive component of marijuana, are mediated by CB1 cannabinoid receptors. However, intraneuronalExpand
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Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488H and attenuates morphine withdrawal
μ‐, δ‐ and κ‐opioid receptors are widely expressed in the central nervous system where they mediate the strong analgesic and mood‐altering actions of opioids, and modulate numerous endogenousExpand
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A behavioural model to reveal place preference to Δ9-tetrahydrocannabinol in mice
Abstract Rationale: The rewarding properties of Δ9- tetrahydrocannabinol (THC) are difficult to demonstrate in rodents using standard procedures. Objective: To evaluate the motivational responses ofExpand
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