• Publications
  • Influence
New evidence for neurotransmitter influences on brain development
TLDR
Both models reveal the effects of very early manipulation of monoamines on forebrain development, and the long-term anomalies that persist into adulthood. Expand
Current status of inverse agonism at serotonin2A (5-HT2A) and 5-HT2C receptors.
TLDR
The existence of constitutive activity at these receptors in vivo, along with the possibility of inverse agonism, provides new avenues for drug development. Expand
Role of the serotonin 5-HT(2A) receptor in learning.
  • J. Harvey
  • Psychology, Medicine
  • Learning & memory
  • 1 September 2003
TLDR
It was concluded that the 5-HT2A receptor demonstrates constitutive activity, and that variations in this activity can produce profound alterations in cognitive states. Expand
Cocaine effects on the developing brain: current status
  • J. Harvey
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
  • 31 January 2004
TLDR
It is found that prenatal exposure to cocaine during neurogenesis produces dysfunctions in signal transduction via the dopamine D(1) receptor and alterations in cortical neuronal development leading to permanent morphological abnormalities in frontocingulate cortex and other brain structures. Expand
Pavlovian conditioning in the rabbit during inactivation of the interpositus nucleus.
1. We have examined the role of the anterior interpositus nucleus (AIP) of the cerebellum in Pavlovian conditioning of the nictitating membrane response (NMR) of the rabbit with the use of reversibleExpand
Serotonergic regulation of associative learning
  • J. Harvey
  • Psychology, Medicine
  • Behavioural Brain Research
  • 15 December 1995
TLDR
It was concluded that 5-HT2A and/or 5- HT2C agonists may provide a new approach to the treatment of learning disorders in aging or Alzheimer's disease. Expand
Acute inactivation of the inferior olive blocks associative learning
  • J. Welsh, J. Harvey
  • Psychology, Medicine
  • The European journal of neuroscience
  • 1 November 1998
TLDR
The experiment demonstrates that an acute disruption in olivary function can block learning, in addition to severely degrading motor control, and indicates the importance of the inferior olive in optimizing learning, perhaps through a general role in regulating temporal processing. Expand
Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors.
TLDR
Evidence that 5-HT2A and 5- HT2C receptor constitutive activity is physiologically relevant in vivo is provided and it is suggested that strong consideration should be given to the impact of constitutive receptor activity on disease and the therapeutic potential of inverse agonism. Expand
MDMA enhances associative and nonassociative learning in the rabbit
  • A. Romano, J. Harvey
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • 1 February 1994
TLDR
MDMA, like the parent compound methylenedioxyamphetamine (MDA), enhances both conditioned and unconditioned responding, and this dual effect appears to be unique to this class of phenylethylamine drugs. Expand
Effects of LSD on learning as measured by classical conditioning of the rabbit nictitating membrane response.
TLDR
The frequency of responding within 800 msec of CS onset or in the 800 msec before shock onset was low, indicating that the effects of LSD on acquisition were not due to sensitization, pseudoconditioning or changes in baseline responding, and reflects the action of the drug on learning. Expand
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