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Endothelin-converting enzyme 2

Known as: Endothelin Converting Enzyme 2, Endothelin Converting Metalloprotease 2, Endothelin-Converting Metalloprotease 2 
An integral membrane metalloendodpeptidase which converts BIG ENDOTHELIN to ENDOTHELIN-1 through hydrolysis of the TRYPTOPHAN (21)-VALINE (22) bond… Expand
National Institutes of Health

Related topics

Related topics

2 relations
ECE2 gene

Broader (1)

Endothelin-Converting Enzymes

Papers overview

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Highly Cited
2004
Highly Cited
2004
Substrate recognition strategy for botulinum neurotoxin serotype A
Clostridal neurotoxins (CNTs) are the causative agents of the neuroparalytic diseases botulism and tetanus. CNTs impair neuronal… Expand
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Highly Cited
2003
Highly Cited
2003
Alzheimer's Disease β-Amyloid Peptide Is Increased in Mice Deficient in Endothelin-converting Enzyme*
The abnormal accumulation of β-amyloid (Aβ) in the brain is an early and invariant feature in Alzheimer's disease (AD) and is… Expand
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Highly Cited
2002
Highly Cited
2002
Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S Proteasome
The 26S proteasome mediates degradation of ubiquitin-conjugated proteins. Although ubiquitin is recycled from proteasome… Expand
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Highly Cited
2002
Highly Cited
2002
DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response.
All cells have stress response pathways that maintain homeostasis in each cellular compartment. In the Gram-negative bacterium… Expand
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Highly Cited
2001
Highly Cited
2001
Degradation of the Alzheimer's Amyloid β Peptide by Endothelin-converting Enzyme*
Deposition of β-amyloid (Aβ) peptides in the brain is an early and invariant feature of all forms of Alzheimer's disease. As with… Expand
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Highly Cited
1999
Highly Cited
1999
Processing of the notch ligand delta by the metalloprotease Kuzbanian.
Signaling by the Notch surface receptor controls cell fate determination in a broad spectrum of tissues. This signaling is… Expand
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Highly Cited
1999
Highly Cited
1999
Interaction of the Metalloprotease Disintegrins MDC9 and MDC15 with Two SH3 Domain-containing Proteins, Endophilin I and SH3PX1*
Metalloprotease disintegrins (a disintegrin and metalloprotease (ADAM) and metalloprotease, disintegrin,cysteine-rich proteins… Expand
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Highly Cited
1996
Highly Cited
1996
The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila.
It has long been suspected that proteolytic activity associated with advancing growth cones may be required for axon extension… Expand
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Highly Cited
1995
Highly Cited
1995
Endothelin-converting Enzyme-2 Is a Membrane-bound, Phosphoramidon-sensitive Metalloprotease with Acidic pH Optimum (*)
Endothelins (ET) are a family of potent vasoactive peptides that are produced from biologically inactive intermediates, termed… Expand
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Highly Cited
1994
Highly Cited
1994
ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
Endothelin-1 (ET-1), a 21-residue vasoactive peptide, is produced in vascular endothelial cells from the 38-residue inactive… Expand
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