Endothelin-converting enzyme 2

Known as: Endothelin Converting Enzyme 2, Endothelin Converting Metalloprotease 2, Endothelin-Converting Metalloprotease 2 
An integral membrane metalloendodpeptidase which converts BIG ENDOTHELIN to ENDOTHELIN-1 through hydrolysis of the TRYPTOPHAN (21)-VALINE (22) bond… (More)
National Institutes of Health

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2 relations
ECE2 gene

Broader (1)

Endothelin-Converting Enzymes

Papers overview

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2015
2015
Endothelin-converting enzyme 2 differentially regulates opioid receptor activity.
BACKGROUND AND PURPOSE Opioid receptor function is modulated by post-activation events such as receptor endocytosis, recycling… (More)
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Highly Cited
2003
Highly Cited
2003
Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.
The abnormal accumulation of beta-amyloid (Abeta) in the brain is an early and invariant feature in Alzheimer's disease (AD) and… (More)
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Highly Cited
2002
Highly Cited
2002
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.
The 26S proteasome mediates degradation of ubiquitin-conjugated proteins. Although ubiquitin is recycled from proteasome… (More)
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Highly Cited
2002
Highly Cited
2002
DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response.
All cells have stress response pathways that maintain homeostasis in each cellular compartment. In the Gram-negative bacterium… (More)
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Highly Cited
2001
Highly Cited
2001
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
Deposition of beta-amyloid (Abeta) peptides in the brain is an early and invariant feature of all forms of Alzheimer's disease… (More)
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1999
1999
Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells.
We have previously reported the intracellular localization of the endothelin-converting enzyme-1 (ECE-1) in human umbilical vein… (More)
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Highly Cited
1999
Highly Cited
1999
Processing of the notch ligand delta by the metalloprotease Kuzbanian.
Signaling by the Notch surface receptor controls cell fate determination in a broad spectrum of tissues. This signaling is… (More)
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1999
1999
Hydrolysis of peptide hormones by endothelin-converting enzyme-1. A comparison with neprilysin.
Endothelins are peptide hormones with a potent vasoconstrictor activity that are also known to function as intercellular… (More)
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Highly Cited
1995
Highly Cited
1995
Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum.
Endothelins (ET) are a family of potent vasoactive peptides that are produced from biologically inactive intermediates, termed… (More)
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Highly Cited
1994
Highly Cited
1994
ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
Endothelin-1 (ET-1), a 21-residue vasoactive peptide, is produced in vascular endothelial cells from the 38-residue inactive… (More)
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