• Publications
  • Influence
Prohibitins act as a membrane‐bound chaperone for the stabilization of mitochondrial proteins
The fact that Phb1/2 is a large multimeric complex, which provides protection of native peptides against proteolysis, suggests a functional homology with protein chaperones with respect to their ability to hold and prevent misfolding of newly synthesized proteins. Expand
The Mitochondrial Prohibitin Complex Is Essential for Embryonic Viability and Germline Function in Caenorhabditis elegans*
A strong loss of function phenotype for prohibitin gene inactivation in a multicellular organism is reported and it is shown for the first time that prohibitins serve an essential role in mitochondrial function during organismal development. Expand
The complete DNA sequence of yeast chromosome III
The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined. This is the first complete sequence analysis of an entire chromosome from any organism. TheExpand
Defective remodeling of cardiolipin and phosphatidylglycerol in Barth syndrome.
Evidence is presented that patients with the rare disorder X-linked cardioskeletal myopathy and neutropenia (Barth syndrome, MIM 302060) have a primary defect in CL and PG remodeling, and an essential factor in this important cellular process is identified for the first time. Expand
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana
Analysis of 17.38 megabases of unique sequence, representing about 17% of the Arabidopsis genome, reveals 3,744 protein coding genes, 81 transfer RNAs and numerous repeat elements. Expand
The mitochondrial PHB complex: roles in mitochondrial respiratory complex assembly, ageing and degenerative disease
It is suggested that the original name for these proteins, the prohibitins, should be amended to reflect their roles as proteins that hold badly formed subunits, thereby keeping the nomenclature already in use but altering its meaning to reflect the proteins' true function more accurately. Expand
MPI1, an essential gene encoding a mitochondrial membrane protein, is possibly involved in protein import into yeast mitochondria.
A gene is cloned and sequenced that can rescue the genetic defect of one group of mutants disturbed in protein import and it is speculated that the Mpi1 protein is a component of a proteinaceous import channel for translocation of precursor proteins across the mitochondrial inner membrane. Expand
Isolation and inactivation of the nuclear gene encoding the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae.
Inactivation of this NADH dehydrogenase does not affect growth on glucose and ethanol, but growth on lactate, pyruvate and acetate is impaired or absent, and this phenotype is discussed in terms of the interplay between different metabolic pathways in yeast. Expand
Hap4p overexpression in glucose-grown Saccharomyces cerevisiae induces cells to enter a novel metabolic state
It is shown that overproduction of a single nuclear transcription factor enables cells to move to a novel state that displays features typical of, but clearly not identical to, other derepressed states. Expand
Mss51p, a putative translational activator of cytochrome c oxidase subunit-1 (COX1) mRNA, is required for synthesis of Cox1p in Saccharomyces cerevisiae
It is shown that an epitope-tagged version of Mss51p (Mss51HA) complements the mutation and can be localized in mitochondria, where it is firmly associated with the mitochondrial inner membrane. Expand