Endothelin-Converting Enzymes

J. Neurochem. (2010) 115, 47–57. 

The deposition of β-amyloid in the brain is a pathological hallmark of Alzheimer disease (AD). Normally, the accumulation of… Expand

The abnormal accumulation of β-amyloid (Aβ) in the brain is an early and invariant feature in Alzheimer's disease (AD) and is… Expand

Deposition of β-amyloid (Aβ) peptides in the brain is an early and invariant feature of all forms of Alzheimer's disease. As with… Expand

Idiopathic pulmonary fibrosis (IPF) is characterized by an alveolitis with epithelial and endothelial damage progressing to… Expand

A critical processing step in endothelin biosynthesis is the conversion of the intermediate "big endothelin" to its biologically… Expand

Endothelin-1 is an endothelium-derived vasoconstrictor peptide, possibly involved in the pathophysiology of cardiovascular… Expand

Endothelin-1 (ET-1), a 21-residue vasoactive peptide, is produced in vascular endothelial cells from the 38-residue inactive… Expand

Endothelin (ET) is a 21-residue potent vasoconstrictive peptide produced by vascular endothelial cells and formed from its… Expand

Since the discovery of endothelium-dependent vasodilation, vascular endothelium has been recognized as an important functional… Expand