Endothelin-Converting Enzymes

Known as: Endothelin Converting Enzyme, Endothelin Converting Enzymes, Endothelin-Converting Enzyme 
Metalloendopeptidases which convert BIG ENDOTHELIN to ENDOTHELIN-1.
National Institutes of Health

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Endothelin Converting Enzyme-1aEndothelin-Converting Enzyme-1bEndothelin-converting enzyme 1Endothelin-converting enzyme 2
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Papers overview

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Highly Cited
2006
Highly Cited
2006
Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.
The deposition of beta-amyloid in the brain is a pathological hallmark of Alzheimer disease (AD). Normally, the accumulation of… (More)
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Highly Cited
2003
Highly Cited
2003
Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.
The abnormal accumulation of beta-amyloid (Abeta) in the brain is an early and invariant feature in Alzheimer's disease (AD) and… (More)
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Highly Cited
2001
Highly Cited
2001
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
Deposition of beta-amyloid (Abeta) peptides in the brain is an early and invariant feature of all forms of Alzheimer's disease… (More)
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Highly Cited
2001
Highly Cited
2001
Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase.
An imbalance of nitric oxide and endothelin plays an important role in cardiovascular disease. Thrombin exerts profound effects… (More)
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Highly Cited
1997
Highly Cited
1997
Angiotensin II increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo: role of ETA receptors for endothelin regulation.
Angiotensin II (Ang II)-stimulated expression of endothelin-1 (ET-1) mRNA is blocked by ETA antagonists in vitro. We studied… (More)
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Review
1996
Review
1996
Molecular pharmacology of endothelin converting enzymes.
A critical processing step in endothelin biosynthesis is the conversion of the intermediate "big endothelin" to its biologically… (More)
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Highly Cited
1994
Highly Cited
1994
ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
Endothelin-1 (ET-1), a 21-residue vasoactive peptide, is produced in vascular endothelial cells from the 38-residue inactive… (More)
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Highly Cited
1994
Highly Cited
1994
Contribution of endogenous generation of endothelin-1 to basal vascular tone
Endothelin-1 is an endothelium-derived vasoconstrictor peptide, possibly involved in the pathophysiology of cardiovascular… (More)
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Highly Cited
1994
Highly Cited
1994
Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells.
Endothelin (ET) is a 21-residue potent vasoconstrictive peptide produced by vascular endothelial cells and formed from its… (More)
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Highly Cited
1988
Highly Cited
1988
A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels.
Since the discovery of endothelium-dependent vasodilation, vascular endothelium has been recognized as an important functional… (More)
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