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Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
TLDR
By targeted disruption of caveolin-1, the main protein component of caveolae, mice that lacked Caveolae were generated, causing aberrations in endothelium-dependent relaxation, contractility, and maintenance of myogenic tone and indicating a fundamental role in organizing multiple signaling pathways in the cell.
Periadventitial fat releases a vascular relaxing factor
TLDR
It is suggested that perivascular adventitial adipose tissue releases a transferable adventitium‐derived relaxing factor that acts by tyrosine kinase‐dependent activation of K+ channels in vascular smooth muscle cells.
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism
TLDR
It is shown that a high-salt diet in rats leads to interstitial hypertonic Na+ accumulation in skin, resulting in increased density and hyperplasia of the lymphcapillary network and VEGFC is identified as an osmosensitive, hypertonicity-driven gene intimately involved in salt-induced hypertension.
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.
TLDR
It is suggested that preeclamptic patients develop stimulatory autoantibodies against the second extracellular AT1 receptor loop, which appears to be PKC-mediated and may participate in the angiotensin II-induced vascular lesions in these patients.
Increased Vascular Smooth Muscle Contractility in TRPC6−/− Mice
TLDR
It is implied that constitutively active TRPC3-type channels, which are up-regulated in TRPC6-deficient smooth muscle cells, are not able to functionally replace TRPC 6, which has distinct nonredundant roles in the control of vascular smooth muscle tone.
Activation of the peripheral endocannabinoid system in human obesity.
TLDR
The findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity and increased in mature human adipocytes compared with in preadipocytes and was found in several human tissues.
A modified quantitative subjective global assessment of nutrition for dialysis patients.
TLDR
It is concluded that the invented malnutrition score, which can be performed in minutes, reliably assesses the nutritional status of haemodialysis patients and may be superior to the conventional SGA.
Contrast media-enhanced magnetic resonance imaging visualizes myocardial changes in the course of viral myocarditis.
BACKGROUND The course of tissue changes in acute myocarditis in humans is not well understood. Diagnostic tools currently available are unsatisfactory. We tested the hypothesis that inflammation is
Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids*
TLDR
It is found that these ω-3 epoxides are highly active as antiarrhythmic agents, suppressing the Ca2+-induced increased rate of spontaneous beating of neonatal rat cardiomyocytes, at low nanomolar concentrations.
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