Endothelial Growth Factors
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New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor growth and metastatic dissemination… Expand Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and an angiogenic inducer in a variety… Expand Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells. Five VEGF isoforms are… Expand The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and… Expand Expression of vascular endothelial growth factor (VEGF) is induced in cells exposed to hypoxia or ischemia. Neovascularization… Expand VPF/VEGF is a multifunctional cytokine that contributes to angiogenesis by both direct and indirect mechanisms. On the one hand… Expand BACKGROUND
Retinal ischemia induces intraocular neovascularization, which often leads to glaucoma, vitreous hemorrhage, and… Expand THE development of new blood vessels (angiogenesis) is required for many physiological processes including embryogenesis, wound… Expand INEFFICIENT vascular supply and the resultant reduction in tissue oxygen tension often lead to neovascularization in order to… Expand CLINICAL and experimental studies suggest that angiogenesis is a prerequisite for solid tumour growth1,2. Several growth factors… Expand