T. Koch

Publications216
h-index33
Citations4,831
Highly Influential Citations113
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Aptamer-based multiplexed proteomic technology for biomarker discovery
TLDR
A versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations, which will enable the discovery of novel biomarkers in a manner that is unencumbered by the incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine.
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Photocross-linking of nucleic acids to associated proteins.
TLDR
The various techniques and chromophores are described and compared, with attention to the photochemical mechanism.
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Using in vitro selection to direct the covalent attachment of human immunodeficiency virus type 1 Rev protein to high-affinity RNA ligands.
TLDR
An in vitro selection procedure called crosslinking SELEX was used to identify RNA sequences that bind with high affinity and crosslink to the Rev protein from human immunodeficiency virus type 1 and yielded RNA molecules with subnanomolar dissociation constants and high efficiency photocrosslinking to Rev.
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Doxazolidine, a proposed active metabolite of doxorubicin that cross-links DNA.
TLDR
Results point to doxoform being a prodrug for doxazolidine that is the reactive species that directly cross-links DNA.
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Quantitative investigation of the photochemical conversion of diaminomaleonitrile to diaminofumaronitrile and 4-amino-5-cyanoimidazole
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Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins.
TLDR
Iodouracil-substituted RNA and DNA were crosslinked regiospecifically to associated proteins in yields of 70 to 94% of bound nucleic acid in an important advance toward the precise identification of contacts in nucleoprotein complexes.
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Formaldehyde in human cancer cells: detection by preconcentration-chemical ionization mass spectrometry.
TLDR
Correlation of natural formaldehyde level with doxorubicin cytotoxicity is a function of the expression of enzymes that neutralize oxidative stress and the drug efflux pump, P-170 glycoprotein.
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Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin.
TLDR
The results suggest a pathway to the inhibition of transcription by reductively activated adriamycin and daunomycin and the proposed molecular structure is duplex DNA containing two molecules of anthracycline bound to a separate strand of the DNA via a methylene group.
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DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair.
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Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine.
TLDR
Two photo-cross-links suggest that the telomere protein may bind telomeric single-stranded DNA by intercalation of aromatic residues into a nucleotide lattice, consistent with the hypothesis that hydrophobic interactions account for the salt resistance of this protein-DNA complex.
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