• Publications
  • Influence
Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms
  • W. Aird
  • Biology, Medicine
  • Circulation research
  • 2 February 2007
Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics, display remarkable heterogeneity in structure and function. This is the first of a 2-part review focused onExpand
  • 1,195
  • 57
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome.
Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high morbidity and mortality rates. The development of novel therapies for sepsis is critically dependent on anExpand
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  • 47
  • PDF
Phenotypic Heterogeneity of the Endothelium: II. Representative Vascular Beds
  • W. Aird
  • Biology, Medicine
  • Circulation research
  • 2 February 2007
Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics, display remarkable heterogeneity in structure and function. This is the second of a 2-part review on theExpand
  • 1,024
  • 40
  • PDF
Endothelial cell heterogeneity
  • W. Aird
  • Medicine
  • Critical care medicine
  • 1 April 2003
ObjectiveTo review recent advances in the field of endothelial cell heterogeneity, and to apply this knowledge to an understanding of site-specific vasculopathy, including acute lung injury. DataExpand
  • 556
  • 19
  • PDF
Down syndrome suppression of tumor growth and the role of the calcineurin inhibitor DSCR1
The incidence of many cancer types is significantly reduced in individuals with Down’s syndrome, and it is thought that this broad cancer protection is conferred by the increased expression of one orExpand
  • 302
  • 18
Vascular Endothelial Growth Factor- and Thrombin-induced Termination Factor, Down Syndrome Critical Region-1, Attenuates Endothelial Cell Proliferation and Angiogenesis*♦
Activation and dysfunction of the endothelium underlie many vascular disorders including atherosclerosis, tumor growth, and inflammation. Endothelial cell activation is mediated by many differentExpand
  • 208
  • 15
Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment
Leukocyte recruitment to sites of infection or inflammation requires multiple adhesive events. Although numerous players promoting leukocyte-endothelial interactions have been characterized,Expand
  • 227
  • 14
PR39, a peptide regulator of angiogenesis
Although tissue injury and inflammation are considered essential for the induction of angiogenesis, the molecular controls of this cascade are mostly unknown. Here we show that a macrophage-derivedExpand
  • 373
  • 13
The Akt-regulated Forkhead Transcription Factor FOXO3a Controls Endothelial Cell Viability through Modulation of the Caspase-8 Inhibitor FLIP*
FLICE-inhibitory protein (FLIP) is a homolog of caspase-8 that lacks catalytic activity and has been shown to be important in protecting endothelial cells from apoptosis. The serine/threonine kinaseExpand
  • 265
  • 13
Vascular-bed--specific hemostasis and hypercoagulable states.
Hemostasis is a physiologic mechanism that maintains blood in a fluid state within the circulation. The coagulation of blood is mediated by cellular components and soluble plasma proteins. InExpand
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