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Liposome-anchored vascular endothelial growth factor aptamers.
Nuclease-resistant aptamers identified from randomized nucleic acid libraries represent a novel class of drug candidates. Aptamers are synthesized chemically and therefore can be readily modifiedExpand
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Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine.
The Oxytricha telomere protein specifically recognizes single-stranded telomeric DNA, forming an extremely salt resistant and kinetically stable nucleoprotein complex. The absence of information onExpand
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Transition metal catalyzed alkene and alkyne hydroacylation.
  • M. Willis
  • Chemistry, Medicine
  • Chemical reviews
  • 10 February 2010
3. Intermolecular Alkene Hydroacylation 734 3.1. Rhodium Catalysis 734 3.2. Ruthenium Catalysis 738 3.3. Cobalt Catalysis 739 3.4. Stereoselective Reactions 740 4. Intramolecular AlkyneExpand
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Palladium-Catalyzed Synthesis of Ammonium Sulfinates from Aryl Halides and a Sulfur Dioxide Surrogate: A Gas- and Reductant-Free Process**
Sulfonyl-derived functional groups populate a broad range of useful molecules and materials, and despite a variety of preparative methods being available, processes which introduce the most basicExpand
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Tandem inverse-electron-demand hetero-/retro-Diels-Alder reactions for aromatic nitrogen heterocycle synthesis.
The merged inverse-electron-demand hetero-Diels-Alder (ihDA)/retro-Diels-Alder (rDA) reaction sequence can be used to rapidly synthesise highly functionalised nitrogen heteroaromatics. The reactionExpand
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Cascade palladium-catalyzed alkenyl aminocarbonylation/ intramolecular aryl amidation: an annulative synthesis of 2-quinolones.
Palladium-catalyzed intermolecular aminocarbonylation/intramolecular amidation cascade sequences can be used to convert a range of 2-(2-haloalkenyl)aryl halide substrates efficiently and selectivelyExpand
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2-Aminobenzaldehydes as Versatile Substrates for Rhodium-Catalyzed Alkyne Hydroacylation: Application to Dihydroquinolone Synthesis**
Alkene and alkyne hydroacylation reactions are archetypal examples of simple addition processes that display excellent atom economy.1 Both reactions result in the formation of a new C–C bond andExpand
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Two-Component Assembly of Thiochroman-4-ones and Tetrahydrothiopyran-4-ones Using a Rhodium-Catalyzed Alkyne Hydroacylation/Thio-Conjugate-Addition Sequence.
β'-Thio-substituted-enones, assembled from the combination of β-tert-butylthio-substituted aldehydes and alkynes, using rhodium catalysis, are shown to smoothly undergo in situ intramolecularExpand
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18F-Trifluoromethanesulfinate Enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides
18F labeling strategies for unmodified peptides with [18F]fluoride require 18F-labeled prosthetics for bioconjugation more often with cysteine thiols or lysine amines. Here we explore selectiveExpand
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