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ERBB4 wt Allele

Known as: ERBB-4, HER4, HER-4 
Human ERBB4 wild-type allele is located within 2q33.3-q34 and is approximately 1156 kb in length. This allele, which encodes receptor tyrosine… 
National Institutes of Health

Related topics

Related topics

13 relations
2q33.3-q34Cell Proliferation Regulatory ProcessERBB2 Signaling PathwayERBB4 Receptor Protein Tyrosine Kinase

Broader (1)

ERBB4 gene

Papers overview

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Highly Cited
2009
Highly Cited
2009
Her4 and Her2/neu Tyrosine Kinase Domains Dimerize and Activate in a Reconstituted in Vitro System*
Her4 (ErbB-4) and Her2/neu (ErbB-2) are receptor-tyrosine kinases belonging to the epidermal growth factor receptor (EGFR) family… 
2009
2009
Somatic Mutations of ErbB4
Cancer drugs targeting ErbB receptors, such as epidermal growth factor receptor and ErbB2, are currently in clinical use. However… 
2005
2005
Endometrial Stromal Sarcomas Frequently Express Epidermal Growth Factor Receptor (EGFR, HER-1): Potential Basis for a New Therapeutic Approach
Endometrial stromal sarcomas are rare malignant mesenchymal uterine tumors. The expressions of different epidermal growth factor… 
2004
2004
Effects of trastuzumab on epidermal growth factor receptor‐dependent and ‐independent human colon cancer cells
Little information is available as to the potential role of HER‐2 as a therapeutic target in colon cancers, which express much… 
Review
2000
Review
2000
A potential role for activated HER-2 in prostate cancer.
The epidermal growth factor (also known as HER or ErbB) family of receptor tyrosine kinases are important mediators of cell… 
Highly Cited
1999
Highly Cited
1999
Heregulin enhances regenerative proliferation in postnatal rat utricular sensory epithelium after ototoxic damage
Hair cell loss due to acoustic and ototoxic damage often leads to hearing and balance impairments. Although a spontaneous event… 
Highly Cited
1998
Highly Cited
1998
Tyrosine Phosphorylation and Proteolysis
Enhancement of tyrosine phosphorylation in cells by the application of pervanadate, an extremely potent phosphotyrosine… 
1998
1998
Two erbB-4 transcripts are expressed in normal breast and in most breast cancers
ErbB-4 is a recently described member of the epidermal growth factor receptor (EGFR) family which together with erbB-3 acts as a… 
Highly Cited
1997
Highly Cited
1997
Association of Csk-homologous Kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in Breast Cancer Cells*
Protein-tyrosine kinases, such as HER-2/ErbB-2, have been specifically linked to breast cancer. The Csk-homologous kinase (CHK… 
Review
1994
Review
1994
Expression of the erbB-2 family of growth factor receptors and their ligands in breast cancers. Implication for tumor biology and clinical behavior.
Transmembrane receptor tyrosine kinases that bind to growth factors transmit signals that are essential to growth and… 
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