Heregulin enhances regenerative proliferation in postnatal rat utricular sensory epithelium after ototoxic damage.

@article{Zheng1999HeregulinER,
  title={Heregulin enhances regenerative proliferation in postnatal rat utricular sensory epithelium after ototoxic damage.},
  author={J. Lisa Zheng and Gretchen Frantz and Annette K. Lewis and Mark X. Sliwkowski and Wei Qiang Gao},
  journal={Journal of neurocytology},
  year={1999},
  volume={28 10-11},
  pages={901-12}
}
Hair cell loss due to acoustic and ototoxic damage often leads to hearing and balance impairments. Although a spontaneous event in chicks and lower vertebrates, hair cell replacement occurs at a much lower frequency in mammals presumably due to a very low rate of supporting cell proliferation following injury. We report here that heregulin, a member of the neuregulin family, dramatically enhances proliferation of supporting cells in postnatal rat utricular epithelial sheet cultures after… CONTINUE READING