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EIF4G1 wt Allele

Known as: EIF4G, Eukaryotic Translation Initiation Factor 4 Gamma, 1 wt Allele, p220 
Human EIF4G1 wild-type allele is located within 3q27-qter and is approximately 21 kb in length. This allele, which encodes eukaryotic translation… Expand
National Institutes of Health

Related topics

Related topics

8 relations
EIF4A2 wt AlleleEukaryotic Initiation Factor-4FEukaryotic Initiation Factor-4GEukaryotic Translation Initiation Factor 4 Gamma 1
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Broader (1)

EIF4G1 gene

Papers overview

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Highly Cited
2013
Highly Cited
2013
Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation.
MicroRNAs (miRNAs) control gene expression through both translational repression and degradation of target messenger RNAs (mRNAs… Expand
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Highly Cited
2009
Highly Cited
2009
Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites.
Viral internal ribosomal entry sites (IRESs) mediate end-independent translation initiation. There are 4 major structurally… Expand
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Highly Cited
2008
Highly Cited
2008
Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation
Cell growth and proliferation require coordinated ribosomal biogenesis and translation. Eukaryotic initiation factors (eIFs… Expand
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Highly Cited
2007
Highly Cited
2007
mTOR signaling: implications for cancer and anticancer therapy.
Mounting evidence links deregulated protein synthesis to tumorigenesis via the translation initiation factor complex eIF4F… Expand
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Highly Cited
2005
Highly Cited
2005
The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus.
Long-lasting synaptic plasticity and memory requires mRNA translation, yet little is known as to how this process is regulated… Expand
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Highly Cited
2005
Highly Cited
2005
Structural roles for human translation factor eIF3 in initiation of protein synthesis.
Protein synthesis in mammalian cells requires initiation factor eIF3, a approximately 750-kilodalton complex that controls… Expand
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Highly Cited
2004
Highly Cited
2004
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.
Common human malignancies acquire derangements of the translation initiation complex, eIF4F, but their functional significance is… Expand
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Highly Cited
1999
Highly Cited
1999
Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray.
Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end- dependent scanning to initiate… Expand
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Highly Cited
1997
Highly Cited
1997
Malignant transformation by overproduction of translation initiation factor eIF4G.
N4G3, a cell line that overexpresses translation initiation factor eIF4G, one of the components of eIF4F, was made by stable… Expand
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Highly Cited
1996
Highly Cited
1996
Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry.
Translation of picornavirus RNA is initiated after ribosomal binding to an internal ribosomal entry site (IRES) within the 5… Expand
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