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EIF4A2 wt Allele

Known as: BM-010, EIF4A, Eukaryotic Translation Initiation Factor 4A, Isoform 2 Gene 
Human EIF4A2 wild-type allele is located in the vicinity of 3q28 and is approximately 7 kb in length. This allele, which encodes eukaryotic… 
National Institutes of Health

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11 relations
3q28ATP HydrolysisEIF4G1 wt AlleleEukaryotic Initiation Factor 4A-II, human

Broader (1)

EIF4A2 gene

Papers overview

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Review
2018
Review
2018
Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity.
2017
2017
Abstract B10: Inhibiting eIF4F-mediated adaptive translatome reprogramming is a salvage strategy for targted melanoma therapy
BRAFV600E mutation is observed in ~50% of melanomas. Once melanomas have progressed with acquired resistance to BRAF-targeted… 
2016
2016
Cul1 promotes melanoma cell proliferation by promoting DEPTOR degradation and enhancing cap-dependent translation.
Cullin1 (Cul1) serves as a rigid scaffold in the SCF (Skp1/Cullin/Rbx1/F-box protein) E3 ubiquitin ligase complex and has been… 
2015
2015
eIF4A1 is a promising new therapeutic target in ER-negative breast cancer
It is well accepted that post-transcriptional control makes a significant contribution to the overall regulation of gene… 
2015
2015
Translation, Pdcd4 and eIF4A
Pdcd4 (programmed cell death 4) has received considerable attention as a tumor suppressor protein in recent years, however, its… 
2015
2015
[Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells].
OBJECTIVE To study the effect of thioridazine on the proliferation and apoptosis of human colorectal cancer SW480 cells… 
2014
2014
LYMPHOID NEOPLASIA Inhibiting CARD 11 translation during BCR activation by targeting the eIF 4 A RNA helicase
During B-lymphocyte development, antigen engagement of the B-cell receptor (BCR) propagates signals promoting cell growth… 
2012
2012
Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3.
2008
2008
Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival
Elevated activity of the eIF4F complex, which controls initiation of cap-dependent mRNA translation, has been linked to cancer… 
1987
1987
Separation of protein synthesis initiation factor eIF4A from a p220-associated cap binding complex activity
A cap binding complex activity was purified from HeLa cells by a procedure which does not depend on the use of cap-affinity… 
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