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EGLN2 gene

Known as: egl-9 family hypoxia-inducible factor 2, EGL9, C. ELEGANS, HOMOLOG OF, 2, PHD1 
National Institutes of Health

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1 relation
EGLN2 protein, human

Papers overview

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Highly Cited
2014
Highly Cited
2014
Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia
We have investigated genetic/pathogenetic factors associated with a new clinical entity in patients presenting with… 
Highly Cited
2014
Highly Cited
2014
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase
The FOXO transcription factors suppress cell proliferation and cell survival by transcriptionally activating specific gene… 
Highly Cited
2009
Highly Cited
2009
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.
Highly Cited
2005
Highly Cited
2005
Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart
The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy… 
Highly Cited
2004
Highly Cited
2004
AIRE Functions As an E3 Ubiquitin Ligase
Autoimmune regulator (AIRE) gene mutation is responsible for the development of autoimmune-polyendocrinopathy-candidiasis… 
Highly Cited
2002
Highly Cited
2002
Sequence Determinants in Hypoxia-inducible Factor-1α for Hydroxylation by the Prolyl Hydroxylases PHD1, PHD2, and PHD3*
Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor induced by hypoxia. Under normoxic conditions, site… 
Highly Cited
2002
Highly Cited
2002
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
Review
2001
Review
2001
Control of pseudohyphae formation in Saccharomyces cerevisiae.
Pseudohyphal growth in both haploid and diploid strains of Saccharomyces cerevisiae reflects concerted changes in different… 
Highly Cited
2001
Highly Cited
2001
Characterization and comparative analysis of the EGLN gene family.
Highly Cited
1994
Highly Cited
1994
Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development
When starved for nitrogen, MATa/MAT alpha cells of the budding yeast Saccharomyces cerevisiae undergo a dimorphic transition to… 
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