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Gender differences in molecular remodeling in pressure overload hypertrophy.
OBJECTIVES The objective of this study was to examine gender differences in left ventricular (LV) function and expression of cardiac genes in response to LV pressure overload due to ascending aorticExpand
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Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue
Age is the most important risk factor for most diseases. Mitochondria play a central role in bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of mitochondriaExpand
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Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle
Posttranslational modifications of the transcriptional coactivator PGC-1α by the deacetylase SIRT1 and the kinase AMPK are involved in exercise-induced mitochondrial biogenesis in skeletal muscle.Expand
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Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression.
OBJECTIVES Activity of mitochondrial respiratory chain complexes with and without mitochondrially encoded subunits was assessed in failing human myocardium together with parameters of mitochondrialExpand
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Obesity induces signs of premature cardiac aging in younger patients: the role of mitochondria.
OBJECTIVES The purpose of the present study was to investigate the influence of obesity on cardiac aging. BACKGROUND Obesity is associated with an increased incidence of left ventricularExpand
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Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series.
Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds endogenous antioxidant capacity. In this paper, we review the specific role of several cardiovascular riskExpand
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Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart
The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the twoExpand
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Caloric restriction delays cardiac ageing in rats: role of mitochondria.
AIMS We tested whether long-term caloric restriction (CR) corrects pre-existing manifestations of cardiac ageing in rats. METHODS AND RESULTS The age-specific effects of CR (-40%, 6 months) onExpand
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Mitochondrial Biogenesis and Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation by Physical Activity
OBJECTIVE Transcriptional peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) plays a key role in mitochondrial biogenesis and energy metabolism and is suggested to be involved inExpand
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The thioredoxin system in aging muscle: key role of mitochondrial thioredoxin reductase in the protective effects of caloric restriction?
Cellular redox balance is maintained by various antioxidative systems. Among those is the thioredoxin system, consisting of thioredoxin, thioredoxin reductase, and NADPH. In the present study, weExpand
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