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  • C. Schofield, P. Ratcliffe
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 2004 (First Publication: 1 May 2004)
  • The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulatedExpand
  • K. Hewitson, L. McNeill, +10 authors C. Schofield
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2002 (First Publication: 19 July 2002)
  • Activity of the hypoxia-inducible factor (HIF) complex is controlled by oxygen-dependent hydroxylation of prolyl and asparaginyl residues. Hydroxylation of specific prolyl residues by 2-oxoglutarateExpand
  • M. Cockman, D. E. Lancaster, +12 authors P. Ratcliffe
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2006 (First Publication: 3 October 2006)
  • Studies on hypoxia-sensitive pathways have revealed a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. The recognition ofExpand