AIRE Functions As an E3 Ubiquitin Ligase

  title={AIRE Functions As an E3 Ubiquitin Ligase},
  author={Daisuke Uchida and Shigetsugu Hatakeyama and Akemi Matsushima and Hongwei Han and Satoshi Ishido and Hak Hotta and Jun Kudoh and Nobuyoshi Shimizu and Vassilis Doucas and Keiichi I Nakayama and Noriyuki Kuroda and Mitsuru Matsumoto},
  journal={The Journal of Experimental Medicine},
  pages={167 - 172}
Autoimmune regulator (AIRE) gene mutation is responsible for the development of autoimmune-polyendocrinopathy-candidiasis ectodermal dystrophy, an organ-specific autoimmune disease with monogenic autosomal recessive inheritance. AIRE is predominantly expressed in medullary epithelial cells of the thymus and is considered to play important roles in the establishment of self-tolerance. AIRE contains two plant homeodomain (PHD) domains, and the novel role of PHD as an E3 ubiquitin (Ub) ligase has… CONTINUE READING


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Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains

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