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ECO-4601
Known as:
TLN-4601
National Institutes of Health
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Related topics
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2 relations
TLN 4601
Broader (1)
diazepinomicin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression
W. Mason
,
K. Bélanger
,
+6 authors
D. Reymond
Journal of Neuro-Oncology
2012
Corpus ID: 20922127
This phase II trial was undertaken to evaluate the efficacy of TLN-4601 in patients with glioblastoma (GBM) at first progression…
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2010
2010
TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation.
Thierry Bertomeu
,
V. Zvereff
,
+6 authors
H. Gourdeau
Biochemical Pharmacology
2010
Corpus ID: 205964311
2010
2010
A phase II trial of TLN-4601 in patients with glioblastoma multiforme (GBM) at first progression.
W. Mason
,
K. Bélanger
,
+6 authors
D. Reymond
2010
Corpus ID: 73946519
2094 Background: TLN-4601 is a structurally novel farnesylated dibenzodiazepinone that has demonstrated broad in vitro…
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2009
2009
Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand
H. Gourdeau
,
J. McAlpine
,
+5 authors
P. Falardeau
Cancer Chemotherapy and Pharmacology
2009
Corpus ID: 22664066
PURPOSE ECO-4601 is a structurally novel farnesylated dibenzodiazepinone discovered through DECIPHER technology, Thallion's…
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2008
2008
579 POSTER Biological and biochemical activity of TLN-4601 in pancreatic cancer
P. M. Campbell
,
J. Fiordalisi
,
+5 authors
C. Der
2008
Corpus ID: 58097341
2007
2007
Phase I study of ECO-4601, a novel Ras pathway inhibitor
P. Kavan
,
D. Melnychuk
,
+8 authors
G. Batist
2007
Corpus ID: 201999880
14128 Background: ECO-4601 is a structurally novel farnesylated dibenzodiazepinone with broad μM in vitro cytotoxic activity, and…
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2007
2007
Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent
P. Falardeau
,
S. Baker
,
+5 authors
G. Batist
2007
Corpus ID: 87512743
B119 Background: ECO-4601 (U.S. Patent 7,101,872) is a structurally novel farnesylated dibenzodiazepinone with broad µM in vitro…
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2007
2007
ECO-4601 inhibits the Ras MAPK signaling pathway by dislodging Ras from the cell plasma membrane
M. Wioland
,
D. Lobreau
,
Gregory L. White
,
P. Falardeau
,
H. Gourdeau
2007
Corpus ID: 82629962
415 ECO-4601 (MW 462), a farnesylated dibenzodiazepinone, is a structurally novel compound identified using Ecopia’s genomic…
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2006
2006
Pharmacokinetic and ADME studies of the antitumor compound ECO-4601
M. Wioland
,
A. Ibrahim
,
+4 authors
H. Gourdeau
2006
Corpus ID: 82972510
3094 ECO-4601 (MW 463) is a structurally novel compound discovered using Ecopia’s genomic DECIPHER® technology platform. The in…
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2005
2005
ECO-4601, a novel anticancer compound, is a peripheral benzodiazepine receptor ligand and induces apoptosis in gliomas
B. Simard
,
H. Gourdeau
,
+5 authors
P. Falardeau
2005
Corpus ID: 89243301
Proc Amer Assoc Cancer Res, Volume 46, 2005 5896 ECO-4601 is a structurally novel farnesylated dibenzodiazepinone (MW 462…
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