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TLN 4601
Known as:
TLN-4601
, TLN4601
National Institutes of Health
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Related topics
Related topics
2 relations
ECO-4601
Broader (1)
diazepinomicin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Pharmacological modulation of oncogenic Ras by natural products and their derivatives: Renewed hope in the discovery of novel anti-Ras drugs.
Shun Ying Quah
,
Michelle Siying Tan
,
Yuan Han Teh
,
J. Stanslas
Pharmacology & therapeutics
2016
Corpus ID: 46567380
2014
2014
Progress in Making Ras as a Druggable Target.
S. Bhattacharyya
Biochemistry & pharmacology : open access
2014
Corpus ID: 26156222
Human RAS gene family consists of 3-functional genes named HRAS, NRAS, and KRAS.1-3 RAS genes provide instruction through a…
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2011
2011
A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression
W. Mason
,
K. Bélanger
,
+6 authors
D. Reymond
Journal of Neuro-Oncology
2011
Corpus ID: 20922127
This phase II trial was undertaken to evaluate the efficacy of TLN-4601 in patients with glioblastoma (GBM) at first progression…
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2010
2010
TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation
N. Boufaied
,
M. Wioland
,
P. Falardeau
,
H. Gourdeau
Anti-cancer drugs
2010
Corpus ID: 23453990
TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered through DECIPHER, Thallion's proprietary drug…
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2010
2010
TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling
P. M. Campbell
,
N. Boufaied
,
+4 authors
H. Gourdeau
Journal of molecular signaling
2010
Corpus ID: 13986331
Background TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered using Thallion's proprietary DECIPHER…
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2010
2010
TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation.
T. Bertomeu
,
V. Zvereff
,
+6 authors
H. Gourdeau
Biochemical pharmacology
2010
Corpus ID: 205964311
2010
2010
A phase II trial of TLN-4601 in patients with glioblastoma multiforme (GBM) at first progression.
W. Mason
,
K. Bélanger
,
+6 authors
D. Reymond
2010
Corpus ID: 73946519
2094 Background: TLN-4601 is a structurally novel farnesylated dibenzodiazepinone that has demonstrated broad in vitro…
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