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TLN 4601

Known as: TLN-4601, TLN4601 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2016
012320102016

Related topics

Related topics

2 relations
ECO-4601

Broader (1)

diazepinomicin

Related mentions per year

Related mentions per year

2004-2016
20002005201020152020
TLN 4601
diazepinomicin
ECO-4601

Papers overview

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Review
2016
Review
2016
Pharmacological modulation of oncogenic Ras by natural products and their derivatives: Renewed hope in the discovery of novel anti-Ras drugs.
Oncogenic rat sarcoma (Ras) is linked to the most fatal cancers such as those of the pancreas, colon, and lung. Decades of… (More)
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2011
2011
A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression
This phase II trial was undertaken to evaluate the efficacy of TLN-4601 in patients with glioblastoma (GBM) at first progression… (More)
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2010
2010
TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation.
TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered through DECIPHER, Thallion's proprietary drug… (More)
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2010
2010
TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling
BACKGROUND TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered using Thallion's proprietary DECIPHER… (More)
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2010
2010
TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation.
TLN-4601 is a farnesylated dibenzodiazepinone isolated from Micromonospora sp. with an antiproliferative effect on several human… (More)
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