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TLN 4601

Known as: TLN-4601, TLN4601 
 
National Institutes of Health

Related topics

Related topics

2 relations
ECO-4601

Broader (1)

diazepinomicin

Papers overview

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Review
2016
Review
2016
Pharmacological modulation of oncogenic Ras by natural products and their derivatives: Renewed hope in the discovery of novel anti-Ras drugs.
Oncogenic rat sarcoma (Ras) is linked to the most fatal cancers such as those of the pancreas, colon, and lung. Decades of… Expand
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2014
2014
Progress in Making Ras as a Druggable Target.
Human RAS gene family consists of 3-functional genes named HRAS, NRAS, and KRAS.1-3 RAS genes provide instruction through a… Expand
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2011
2011
A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression
This phase II trial was undertaken to evaluate the efficacy of TLN-4601 in patients with glioblastoma (GBM) at first progression… Expand
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2010
2010
TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling
Background TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered using Thallion's proprietary DECIPHER… Expand
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2010
2010
TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation.
TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered through DECIPHER, Thallion's proprietary drug… Expand
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2010
2010
TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation.
TLN-4601 is a farnesylated dibenzodiazepinone isolated from Micromonospora sp. with an antiproliferative effect on several human… Expand
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2010
2010
A phase II trial of TLN-4601 in patients with glioblastoma multiforme (GBM) at first progression.
2094 Background: TLN-4601 is a structurally novel farnesylated dibenzodiazepinone that has demonstrated broad in vitro… Expand
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