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TLN 4601

Known as: TLN-4601, TLN4601 
National Institutes of Health

Related topics

Related topics

2 relations
ECO-4601

Broader (1)

diazepinomicin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Pharmacological modulation of oncogenic Ras by natural products and their derivatives: Renewed hope in the discovery of novel anti-Ras drugs.
Oncogenic rat sarcoma (Ras) is linked to the most fatal cancers such as those of the pancreas, colon, and lung. Decades of… Expand
2014
2014
Progress in Making Ras as a Druggable Target.
  • S. Bhattacharyya
  • Biochemistry & pharmacology : open access
  • 2014
    • Corpus ID: 26156222
Human RAS gene family consists of 3-functional genes named HRAS, NRAS, and KRAS.1-3 RAS genes provide instruction through a… Expand
2011
2011
A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression
This phase II trial was undertaken to evaluate the efficacy of TLN-4601 in patients with glioblastoma (GBM) at first progression… Expand
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2010
2010
TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling
Background TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered using Thallion's proprietary DECIPHER… Expand
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2010
2010
TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation
TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered through DECIPHER, Thallion's proprietary drug… Expand
2010
2010
TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation.
TLN-4601 is a farnesylated dibenzodiazepinone isolated from Micromonospora sp. with an antiproliferative effect on several human… Expand
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2010
2010
A phase II trial of TLN-4601 in patients with glioblastoma multiforme (GBM) at first progression.
2094 Background: TLN-4601 is a structurally novel farnesylated dibenzodiazepinone that has demonstrated broad in vitro… Expand
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