E3 SUMO-Protein Ligase PIAS1

Known as: AR Interacting Protein, PIAS1, Gu-Binding Protein 
E3 SUMO-protein ligase PIAS1 (651 aa, ~72 kDa) is encoded by the human PIAS1 gene. This protein is involved in the mediation of protein sumoylation.
National Institutes of Health

Related topics

Related topics

8 relations
Enzyme GeneInterferon Signaling ProcessLigase GeneNucleoplasm
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.
The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
DNA double-strand breaks (DSBs) are highly cytotoxic lesions that are generated by ionizing radiation and various DNA-damaging… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signaling.
Attachment of SUMO to proteins regulates protein-protein interactions through noncovalent binding of the SUMO moiety to… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Ebola Zaire Virus Blocks Type I Interferon Production by Exploiting the Host SUMO Modification Machinery
Ebola Zaire virus is highly pathogenic for humans, with case fatality rates approaching 90% in large outbreaks in Africa. The… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Proinflammatory Stimuli Induce IKKα-Mediated Phosphorylation of PIAS1 to Restrict Inflammation and Immunity
How inflammatory stimuli signal to the nucleus to restrict inflammation is poorly understood. Protein inhibitor of activated… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.
Nuclear matrix attachment regions (MARs) are regulatory DNA sequences that are important for higher-order chromatin organization… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Transcription factor Sp3 is silenced through SUMO modification by PIAS1.
Sp3 is a ubiquitous transcription factor closely related to Sp1. Here we show that Sp3 is a target for SUMO modification in vivo… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription.
The androgen receptor (AR) has been shown to be modified by SUMO-1, a ubiquitin-like protein. Recently we showed that PIAS family… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Involvement of PIAS1 in the sumoylation of tumor suppressor p53.
Sumoylation of p53 by the ubiquitin-like protein, SUMO-1/sentrin/PIC1, has been shown to stimulate its transcriptional activation… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Inhibition of Stat1-mediated gene activation by PIAS1.
STAT (signal transducer and activator of transcription) proteins are latent cytoplasmic transcription factors that become… (More)
Is this relevant?