E3 SUMO-Protein Ligase PIAS1

Known as: AR Interacting Protein, PIAS1, Gu-Binding Protein 
E3 SUMO-protein ligase PIAS1 (651 aa, ~72 kDa) is encoded by the human PIAS1 gene. This protein is involved in the mediation of protein sumoylation.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad… (More)
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Highly Cited
2009
Highly Cited
2009
DNA double-strand breaks (DSBs) are highly cytotoxic lesions that are generated by ionizing radiation and various DNA-damaging… (More)
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Highly Cited
2009
Highly Cited
2009
Attachment of SUMO to proteins regulates protein-protein interactions through noncovalent binding of the SUMO moiety to… (More)
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Highly Cited
2009
Highly Cited
2009
Ebola Zaire virus is highly pathogenic for humans, with case fatality rates approaching 90% in large outbreaks in Africa. The… (More)
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Highly Cited
2007
Highly Cited
2007
How inflammatory stimuli signal to the nucleus to restrict inflammation is poorly understood. Protein inhibitor of activated… (More)
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Highly Cited
2003
Highly Cited
2003
Nuclear matrix attachment regions (MARs) are regulatory DNA sequences that are important for higher-order chromatin organization… (More)
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Highly Cited
2002
Highly Cited
2002
Sp3 is a ubiquitous transcription factor closely related to Sp1. Here we show that Sp3 is a target for SUMO modification in vivo… (More)
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Highly Cited
2002
Highly Cited
2002
The androgen receptor (AR) has been shown to be modified by SUMO-1, a ubiquitin-like protein. Recently we showed that PIAS family… (More)
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Highly Cited
2001
Highly Cited
2001
Sumoylation of p53 by the ubiquitin-like protein, SUMO-1/sentrin/PIC1, has been shown to stimulate its transcriptional activation… (More)
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Highly Cited
1998
Highly Cited
1998
STAT (signal transducer and activator of transcription) proteins are latent cytoplasmic transcription factors that become… (More)
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