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E3 SUMO-Protein Ligase PIAS1

Known as: AR Interacting Protein, PIAS1, Gu-Binding Protein 
E3 SUMO-protein ligase PIAS1 (651 aa, ~72 kDa) is encoded by the human PIAS1 gene. This protein is involved in the mediation of protein sumoylation.
National Institutes of Health

Related topics

Related topics

8 relations
Enzyme GeneInterferon Signaling ProcessLigase GeneNucleoplasm

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Phosphorylation of Protein Inhibitor of Activated STAT1 (PIAS1) by MAPK-Activated Protein Kinase-2 Inhibits Endothelial Inflammation via Increasing Both PIAS1 Transrepression and SUMO E3 Ligase…
Objective—Protein inhibitor of activated signal transducer and activator of transcription-1 (PIAS1) is known to function as small… 
Highly Cited
2012
Highly Cited
2012
Molecular and Cellular Pathobiology The SUMOE 3-ligase PIAS 1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA
The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad… 
2012
2012
Protein inhibitor of activated STAT-1 is downregulated in gastric cancer tissue and involved in cell metastasis.
Protein inhibitor of activated STAT-1 (PIAS1) is a novel modulator of the JAK/STAT signaling pathway that negatively… 
2011
2011
mRNA expression of BRCA1, PIAS1, and PIAS4 and survival after second-line docetaxel in advanced gastric cancer.
Breast cancer susceptibility gene 1 (BRCA1) has a central role in chemotherapy-induced DNA damage response. The protein inhibitor… 
2011
2011
SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.
The central nervous system regulates neuronal excitability by macromolecular signalling complexes that consist of functionally… 
2007
2007
Overexpression of the mTOR alpha4 phosphoprotein activates protein phosphatase 2A and increases Stat1α binding to PIAS1
Highly Cited
2002
Highly Cited
2002
Protein Inhibitors of Activated STAT Resemble Scaffold Attachment Factors and Function as Interacting Nuclear Receptor Coregulators*
Protein inhibitor of activated STAT1 (PIAS1) functions as a nuclear receptor coregulator and is expressed in several cell types… 
2001
2001
Induction of Apoptosis by Protein Inhibitor of Activated Stat1 through c-Jun NH2-terminal Kinase Activation*
Members of the protein inhibitor of activated signal transducer and activator of transcription (STAT) family (PIAS family) of… 
Highly Cited
2000
Highly Cited
2000
In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium.
Inducible nitric oxide synthase-2 (NOS2) expression has been shown to be reduced in cystic fibrosis (CF) epithelial cells… 
Highly Cited
1998
Highly Cited
1998
Beta-galactoside-binding protein (beta GBP) alters the cell cycle, up-regulates expression of the alpha- and beta-chains of the IFN-gamma receptor, and triggers IFN-gamma-mediated apoptosis of…
In this paper, the effects of beta-galactoside binding protein (beta GBP), the LGALS1 gene product, on the cell cycle progression… 
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