SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.

@article{Dtting2011SUMOEL,
  title={SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.},
  author={Eva D{\"u}tting and Nadja Schr{\"o}der-Kress and Heinrich Sticht and Ralf Enz},
  journal={The Biochemical journal},
  year={2011},
  volume={435 2},
  pages={365-71}
}
The central nervous system regulates neuronal excitability by macromolecular signalling complexes that consist of functionally related proteins, including neurotransmitter receptors, enzymes and scaffolds. The composition of these signal complexes is regulated by post-translational modifications, such as phosphorylation and SUMOylation (SUMO is small ubiquitin-related modifier). In the present study, we searched for proteins interacting with the intracellular C-termini of the metabotropic… CONTINUE READING