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The Androgen Axis in Recurrent Prostate Cancer
Novel therapies for recurrent prostate cancer should target androgen receptor directly and prevent the formation of androgens within prostate cancer tissue at levels sufficient to activate androgenceptor.
Immunocytochemical localization of corticotropin-releasing factor (CRF) in the rat brain.
The widespread but selective distribution of neurons containing CRF-like immunoreactivity supports the neuroendocrine role of this peptide and suggests that CRF, similarly to other neuropeptides, may also function as a neuromodulator throughout the brain.
Influence of estrogens on mouse uterine epidermal growth factor precursor protein and messenger ribonucleic acid.
Investigating whether an epidermal growth factor (EGF)-related polypeptide originates in the uterus of the immature or adult mouse under normal or altered estrogen status suggests that EGF occurs predominantly as the membrane-bound precursor form in this organ, as has been previously shown for the kidney.
Characterization of antisera to glutamate and aspartate.
Glu- like immunoreactivity in rat dorsal root ganglia and somatosensory cortex, and the comparative distribution of Glu- and Asp-like immunoreactivities in the latter tissue, are presented as examples of staining patterns obtained with the two antisera.
New data on the immunocytochemical localization of thyrotropin-releasing hormone in the rat central nervous system.
The distribution of TRH-immunoreactive structures in the rat central nervous system suggests that TRH functions both as a neuroendocrine regulator in the hypothalamus and as a neurotransmitter or neuromodulator throughout the CNS.
HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human.
It is revealed that the 0.9-kb messenger RNA (mRNA) is most abundant in human caput; there is much less of it in corpus and little in cauda; and testosterone replacement maintained HE2 mRNA 3- to 5-fold higher than castrate levels, indicating its androgen dependence.
Immunocytochemical Localization of β-Endorphin-Containing Neurons in the Rat Brain
β-Endorphin-containing neurons in the rat central nervous system were localized using three improvements of the unlabelled antibody-enzyme bridge immunocytochemical technique. These improvements were
Estradiol stimulates tyrosine phosphorylation of the insulin-like growth factor-1 receptor and insulin receptor substrate-1 in the uterus.
Since hormonal activation of IRS-1 is epithelial, estrogen-specific, and initiated before maximal DNA synthesis occurs following treatment with hormone, this protein, as part of the IGF-1R pathway, may be important in mediating estrogen-stimulated proliferation in the uterus.