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E 64c

Known as: E 64-c, E-64c, E64C 
 
National Institutes of Health

Papers overview

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2014
2014
MDMA induces cardiac contractile dysfunction through autophagy upregulation and lysosome destabilization in rats.
The underlying mechanisms of cardiotoxicity of 3,4-methylenedioxymethylamphetamine (MDMA, "ecstasy") abuse are unclear. Autophagy… Expand
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Highly Cited
2004
Highly Cited
2004
3-methyladenine inhibits autophagy in tobacco culture cells under sucrose starvation conditions.
Tobacco (Nicotiana tabacum) culture cells perform autophagy and degrade cellular proteins in response to sucrose starvation. When… Expand
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1998
1998
Striated muscle calcium-stimulated cysteine protease (calpain-like) activity promotes myeloperoxidase activity with exercise
Abstract An inflammatory response triggered by neutrophil accumulation into muscle tissue is thought to occur with exercise… Expand
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Highly Cited
1996
Highly Cited
1996
Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary…
Insulin inhibition of the secretion of apolipoprotein B (apo B) was studied in primary cultures of rat hepatocytes by using… Expand
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1992
1992
Ester and amide derivatives of E64c as inhibitors of platelet calpains.
Ester and amide derivatives of E64c, (+)-(2S,3S)-3-[[(S)-3-methyl-1- [(3-methylbutyl)carbamoyl]butyl]carbamoyl]-2… Expand
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1992
1992
Effects of selective inhibition of cathepsin B and general inhibition of cysteine proteinases on lysosomal proteolysis in rat liver in vivo and in vitro.
Intraperitoneal administration of N-(L-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-prolin e (CA-074) to rats at a dose… Expand
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1990
1990
Suppressive effect of E-64c on ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats
Microtubule-associated protein 2 (MAP2) levels in the left cerebral hemisphere decreased significantly 3 days after occlusion of… Expand
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1986
1986
In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64.
E-64 isolated from a culture of Aspergillus japonicus is a specific inhibitor of cysteine proteinases. E-64-c, a synthetic analog… Expand
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1985
1985
Regulation of protein degradation in muscle by calcium. Evidence for enhanced nonlysosomal proteolysis associated with elevated cytosolic calcium.
Calcium-dependent regulation of intracellular protein degradation was studied in isolated rat skeletal muscles incubated in vitro… Expand
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1983
1983
Identification of Ca2+-activated neutral protease in the peripheral nerve and its effects on neurofilament degeneration.
Rat sciatic nerve segments were incubated in five different media. Disappearance of neurofilament (NF) triplet proteins (200K… Expand
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