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E 64c

Known as: E 64-c, E-64c, E64C 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
A Reactive, Rigid GdIII Labeling Tag for In-Cell EPR Distance Measurements in Proteins.
The cellular environment of proteins differs considerably from in vitro conditions under which most studies of protein structures… 
Review
1999
Review
1999
Structural basis of inhibition of cysteine proteases by E-64 and its derivatives.
This paper focuses on the inhibitory mechanism of E-64 and its derivatives (epoxysuccinyl-based inhibitors) with some cysteine… 
Highly Cited
1998
Highly Cited
1998
Striated muscle calcium-stimulated cysteine protease (calpain-like) activity promotes myeloperoxidase activity with exercise
Abstract An inflammatory response triggered by neutrophil accumulation into muscle tissue is thought to occur with exercise… 
Highly Cited
1996
Highly Cited
1996
Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary…
Insulin inhibition of the secretion of apolipoprotein B (apo B) was studied in primary cultures of rat hepatocytes by using… 
1992
1992
Ester and amide derivatives of E64c as inhibitors of platelet calpains.
Ester and amide derivatives of E64c, (+)-(2S,3S)-3-[[(S)-3-methyl-1- [(3-methylbutyl)carbamoyl]butyl]carbamoyl]-2… 
Highly Cited
1991
Highly Cited
1991
Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo
Highly Cited
1991
Highly Cited
1991
Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution.
E-64-c, a synthetic cysteine protease inhibitor designed from E-64, binds to papain through a thioether covalent bond. The x-ray… 
Highly Cited
1989
Highly Cited
1989
Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d.
Highly Cited
1986
Highly Cited
1986
In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64.
E-64 isolated from a culture of Aspergillus japonicus is a specific inhibitor of cysteine proteinases. E-64-c, a synthetic analog… 
Highly Cited
1985
Highly Cited
1985
Regulation of protein degradation in muscle by calcium. Evidence for enhanced nonlysosomal proteolysis associated with elevated cytosolic calcium.
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