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E 4177

Known as: E-4177, E4177 
National Institutes of Health

Papers overview

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2005
2005
Up-Regulation of Akt and eNOS Induces Vascular Smooth Muscle Cell Differentiation in Hypertension In Vivo
Recent studies have shown that angiotensin II type 1 (AT1) receptor-mediated Akt activation induces vascular smooth muscle cell… 
2002
2002
Angiotensin II and IGF-I may interact to regulate tubulointerstitial cell kinetics and phenotypic changes in hypertensive rats.
Angiotensin II and insulin-like growth factor-I (IGF-I) are known to be actively involved in the pathogenesis of progressive… 
1999
1999
Functional and binding studies of insurmountable antagonism of 606A, a novel AT1-receptor antagonist in rabbit tissues.
Angiotensin AT1-receptor antagonists can be classified into two types, surmountable and insurmountable ones, based on the way… 
1998
1998
Pharmacokinetics, metabolism and pharmacodynamics of a benzimidazole angiotensin II type 1 receptor antagonist in the beagle dog and cynomologus monkey.
1. The pharmacokinetics and disposition of E4177, an angiotensin II (Ang II) type 1 receptor antagonist, were studied in the… 
1997
1997
Regulation of aldosterone synthase cytochrome P450 (CYP11B2) and 11 beta-hydroxylase cytochrome P450 (CYP11B1) expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II…
Changes in the mRNA levels for aldosterone synthase cytochrome P450 (CYP11B2 or P450aldo) and 11 beta hydroxylase cytochrome P450… 
1997
1997
Determination of angiotensin II receptor antagonist (E4177) in human plasma and urine by high-performance liquid chromatography.
1996
1996
Localization of a novel non-peptide angiotensin II type 1 receptor antagonist, E4177, in rat adrenal glomerulosa.
We investigated the distribution of a novel angiotensin II type 1 (AT1) receptor antagonist, E4177 (4'-[2-cyclopropyl-7-methyl-3H… 
1995
1995
Pulmonary edema induced by angiotensin II in rats.
We performed this study to demonstrate the experimental procedure for inducing pulmonary edema by angiotensin II (AT II) in rats… 
1994
1994
Localization and quantitation of active renin in monkey kidney by radioinhibitor binding and in vitro autoradiography.
We developed an in vitro autoradiographic method to localize and quantify active renin in primate tissues. Active renin in monkey… 
1993
1993
In vitro pharmacology of a novel non-peptide angiotensin II-receptor antagonist, E4177.
E4177, 3-[(2'-carboxybiphenyl-4-yl)methyl]-2-cyclopropyl-7-methyl-3H- imidazo[4,5-b]pyridine, was characterized by in vitro… 
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