Effectiveness of Aldosterone Blockade in Patients With Diabetic Nephropathy
The possibility that aldosterone blockade may represent optimal therapy for patients with early diabetic nephropathy who show ald testosterone escape during ACE inhibitor treatment and who no longer show maximal antiproteinuric effects of ACE inhibition is suggested.
Peroxisome Proliferator-Activated Receptor γ Ligands Inhibit Rho/Rho Kinase Pathway by Inducing Protein Tyrosine Phosphatase SHP-2
Collectively, PPARγ ligands inhibit the Rho/Rho kinase pathway through upregulation of cytosolic SHP-2 expression and inactivation of Vav, and may contribute to the hemodynamic, in addition to metabolic, action in hypertensive metabolic syndrome.
Vessel- and Vasoconstrictor-Dependent Role of Rho/Rho-Kinase in Renal Microvascular Tone
A predominant role of Rho/Rho-kinase is demonstrated in mediating the basal and Ang II-induced tone of afferent, but not efferent, arterioles, using isolated perfused rat hydronephrotic kidney.
Pioglitazone Lowers Systemic Asymmetric Dimethylarginine by Inducing Dimethylarginine Dimethylaminohydrolase in Rats
A PPARγ ligand was found to increase NO production partly by upregulating tissue DDAH-II expression and decreasing systemic ADMA levels, finding this mechanism constitutes a direct action on renal tubular cells, but is less likely to be responsible for the blood pressure-lowering effects of PParγ ligands.
Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats.
- T. Kanda, S. Wakino, K. Hayashi, K. Homma, Y. Ozawa, T. Saruta
- Medicine, BiologyKidney International
- 1 December 2003
The inhibition of Rho-kinase may constitute a therapeutic strategy for the treatment of renal injury in part through the p27kip1 up-regulation and the subsequent inhibition of cell proliferation and macrophage recruitment.
Rho‐kinase as a molecular target for insulin resistance and hypertension
Collectively, Rho‐kinase is responsible for the impairment of insulin signaling and may constitute a critical mediator linking between metabolic and hemodynamic abnormalities in insulin resistance.
Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease.
Differential Regulation of Elevated Renal Angiotensin II in Chronic Renal Ischemia
Renal Ang I levels increased only in clipped kidneys, whereas intrarenal Ang II contents were elevated in both clipped and nonclipped kidneys, which contributed to the altered renal hemodynamics and microvascular tone.
Free Radical Activity Depends on Underlying Vasoconstrictors in Renal Microcirculation
- Y. Ozawa, K. Hayashi, T. Saruta
- Biology, MedicineClinical and experimental hypertension
- 1 January 2004
The role ofFree radicals in afferent arteriolar tone varies, depending on the underlying vasoconstrictor stimuli, with greater contribution of free radicals to angiotensin II‐induced constriction.
Transient receptor potential channels in rat renal microcirculation: actions of angiotensin II.
The data provide evidence that Ang II elicits IP3CR, possibly inducing a cellular response that activates voltage-dependent calcium channels on afferent arterioles, and calcium influx sensitive to SKF-96365.