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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
  • T. Omura, R. Sato
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1 July 1964
The presence in mammalian liver microsomes of a carbon monoxide-binding pigment has been reported by Klingenberg (1) and by Garfinkel (2). The CO compound of the reduced pigment has an intenseExpand
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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.
  • T. Omura, R. Sato
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1 July 1964
The presence in mammalian liver microsomes of a carbon monoxide-binding pigment has been reported by Klingenberg (1) and by Garfinkel (2). The CO compound of the reduced pigment has an intenseExpand
  • 2,846
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A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s.
Previous studies of bovine CYP11B1 gene regulation revealed six cis-acting elements, Ad1, Ad2, Ad3, Ad4, Ad5, and Ad6, in the 5' upstream region of the gene. Ad4 site was a positive transcriptionExpand
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A new cytochrome in liver microsomes.
  • T. Omura, R. Sato
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1 April 1962
8. HEPPEL, L. A., in S. P. COLOWICK AND N. 0. KAPLAN (Editors), Methods in enzymology, Vol. II, Academic Press, Inc., New York, 1955, p. 575. CANTONI, G. L., in M. FLORKIN AND H. S. MASON (Editors),Expand
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Forty years of cytochrome P450.
  • T. Omura
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 29 December 1999
The term "cytochrome P450" first appeared in literature in 1962. It was a microsomal membrane-bound hemoprotein without known physiological functions at that time and was characterized by a uniqueExpand
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A mitochondrial import factor purified from rat liver cytosol is an ATP‐dependent conformational modulator for precursor proteins.
Rat liver cytosol contained an activity that stimulated the import of wheat germ lysate‐synthesized precursor proteins into mitochondria. The activity was purified 10,000‐fold from the cytosol as aExpand
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Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP.
We have examined the transcriptional activity of four cis-elements, Ad1(CRE), Ad2, Ad3, and Ad4, that are present in the promoter of the bovine CYP11B (11 beta-hydroxylase P-450) gene usingExpand
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Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily.
Bovine cytochrome P-450(11 beta) gene (CYP11B) has six different cis-acting elements, Ad1, Ad2, Ad3, Ad4, Ad5, and Ad6, in the promoter region. The Ad4 site also exists in the promoter regions ofExpand
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Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development.
We investigated the expression of Ad4BP (also known as SF-1), a transcription factor regulating steroidogenic P-450 genes, in the steroidogenic tissues such as adrenal glands, testes and ovariesExpand
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