T. Omura

Publications211
h-index55
Citations25,693
Highly Influential Citations595
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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
  • T. Omura, R. Sato
  • Biology, Chemistry
    The Journal of biological chemistry
  • 1 July 1964
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
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Cytochrome P450
TLDR
It is shown that in allylic hydroxyl ations (catalyzed by either model metalloporphyrins or cytochrome P450) rehydridization could occur to yield multiple products.
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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.
  • T. Omura, R. Sato
  • Biology, Chemistry
    The Journal of biological chemistry
  • 1 July 1964
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
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A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s.
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A new cytochrome in liver microsomes.
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Forty years of cytochrome P450.
  • T. Omura
  • Biology
    Biochemical and biophysical research…
  • 29 December 1999
TLDR
Oxidative metabolism of foreign hydrophobic compounds as the first step of their excretion from the animal body is apparently another major function of cytochrome P450, which protects animals from noxious foreign compounds, man-created and natural.
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A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes.
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Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development.
TLDR
It is suggested that the Müllerian inhibitory substance gene may be a target of Ad4BP since this gene has a conserved Ad4-binding site within the promoter, which is recognized by Ad4 BP expressed in the fetal testes.
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Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP.
TLDR
Only Ad1(CRE), a CRE homolog, showed forskolin-dependent transcriptional activity in adrenal tumor Y-1 cells, whereas the other elements were not able to stimulate transcription by themselves.
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Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily.
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