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Drug Screening Assays, Antitumor
Known as:
Cancer Drug Tests
, Antitumor Drug Screening Assay
, Drug Test, Cancer
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Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and…
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National Institutes of Health
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Related topics
Related topics
2 relations
Tumor Cells, Cultured
standards characteristics
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Irinotecan Drug-Eluting Beads in the Treatment of Chemo-Naive Unresectable Colorectal Liver Metastasis with Concomitant Systemic Fluorouracil and Oxaliplatin: Results of Pharmacokinetics and Phase I…
R. Martin
,
C. Scoggins
,
+4 authors
Vivek R. Sharma
Journal of Gastrointestinal Surgery
2012
Corpus ID: 12960137
PurposeThe primary objective of this study is to evaluate the safety, tolerance, and pharmacokinetic profile of liver-directed…
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Review
2012
Review
2012
In Vitro Evaluation of Hepatic Transporter-Mediated Clinical Drug-Drug Interactions: Hepatocyte Model Optimization and Retrospective Investigation
Y. Bi
,
Emi Kimoto
,
+9 authors
Yurong Lai
Drug Metabolism And Disposition
2012
Corpus ID: 735491
To assess the feasibility of using sandwich-cultured human hepatocytes (SCHHs) as a model to characterize transport kinetics for…
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Review
2005
Review
2005
Cell-based models to study hepatic drug metabolism and enzyme induction in humans
M. Vermeir
,
P. Annaert
,
R. Mamidi
,
D. Roymans
,
W. Meuldermans
,
G. Mannens
Expert Opinion on Drug Metabolism & Toxicology
2005
Corpus ID: 12444363
Cell-based in vitro models are invaluable tools in elucidating the pharmacokinetic profile of a drug candidate during its drug…
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Review
2002
Review
2002
Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein.
J. Hochman
,
M. Yamazaki
,
T. Ohe
,
J. Lin
Current drug metabolism
2002
Corpus ID: 31545132
The pharmacological effects of a drug are highly dependent on the absorption, metabolism, elimination, and distribution of the…
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Highly Cited
1989
Highly Cited
1989
Ultrasound enhanced drug toxicity on Chinese hamster ovary cells in vitro.
A. H. Saad
,
G. Hahn
Cancer Research
1989
Corpus ID: 5845213
Chinese hamster ovary cells (HA1) were exposed to therapeutic ultrasound (F = 2.025 MHz) in the presence of various drugs at…
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Review
1985
Review
1985
The use of microorganisms for the study of drug metabolism
A. Clark
,
J. McChesney
,
C. D. Hufford
Medicinal research reviews (Print)
1985
Corpus ID: 26304896
The potential for the use of microorganisms as tools in the study of drug metabolism appears to be unlimited. The selected…
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Highly Cited
1982
Highly Cited
1982
The development and in vitro evaluation of acrylic strips and dialysis tubing for local drug delivery.
M. Addy
,
L. Rawle
,
R. Handley
,
H. Newman
,
J. Coventry
The Journal of Periodontology
1982
Corpus ID: 35208901
This study reports on the development of drug containing acrylic strips for delivering antimicrobial agents and compares the in…
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Highly Cited
1979
Highly Cited
1979
Correlation between benzodiazepine receptor occupation and anticonvulsant effects of diazepam
S. Paul
,
P. Syapin
,
B. Paugh
,
V. Moncada
,
P. Skolnick
Nature
1979
Corpus ID: 4271307
The benzodiazepines are potent anticonvulsants for a wide variety of experimental and clinical seizure disorders1,2. The…
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Highly Cited
1978
Highly Cited
1978
Carrier-mediated transport of daunorubicin, adriamycin, and rubidazone in Ehrlich ascites tumour cells.
T. Skovsgaard
Biochemical Pharmacology
1978
Corpus ID: 30911780
Highly Cited
1978
Highly Cited
1978
Ultrastructure of adult rat hepatocytes cultured on floating collagen membranes.
C. Sattler
,
G. Michalopoulos
,
G. Sattler
,
H. Pitot
Cancer Research
1978
Corpus ID: 22800962
The ultrastructure of primary hepatocytes cultured for 2 to 17 days on floating collagen membrane was evaluated. A pellet of the…
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