Drug Screening Assays, Antitumor

Known as: Cancer Drug Tests, Antitumor Drug Screening Assay, Drug Test, Cancer 
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and… (More)
National Institutes of Health

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2 relations
Tumor Cells, Culturedstandards characteristics

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Highly Cited
2012
Highly Cited
2012
Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation
There is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex in vivo… (More)
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Highly Cited
2007
Highly Cited
2007
Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis.
OBJECTIVES We sought to determine whether nonresponsiveness to clopidogrel as revealed by high in vitro post-treatment platelet… (More)
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Highly Cited
2006
Highly Cited
2006
National surveillance of emergency department visits for outpatient adverse drug events.
CONTEXT Adverse drug events are common and often preventable causes of medical injuries. However, timely, nationally… (More)
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Review
2005
Review
2005
Predicting in vivo drug interactions from in vitro drug discovery data
In vitro screening for drugs that inhibit cytochrome P450 enzymes is well established as a means for predicting potential… (More)
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Highly Cited
2001
Highly Cited
2001
Rational use of in vitro P-glycoprotein assays in drug discovery.
P-glycoprotein (Pgp) affects the absorption, distribution, and clearance of a variety of compounds. Thus, identification of… (More)
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Review
1998
Review
1998
Inhibition and induction of cytochrome P450 and the clinical implications.
The cytochrome P450s (CYPs) constitute a superfamily of isoforms that play an important role in the oxidative metabolism of drugs… (More)
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Review
1998
Review
1998
In vitro and in vivo drug interactions involving human CYP3A.
Cytochrome P4503A (CYP3A) is importantly involved in the metabolism of many chemically diverse drugs administered to humans… (More)
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Highly Cited
1997
Highly Cited
1997
Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery.
BACKGROUND The antineoplastic compound paclitaxel (Taxol) causes an increased assembly of extraordinarily stable microtubules… (More)
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Highly Cited
1995
Highly Cited
1995
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is… (More)
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Highly Cited
1991
Highly Cited
1991
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
We describe here the development and implementation of a pilot-scale, in vitro, anticancer drug screen utilizing a panel of 60… (More)
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