Drug Screening Assays, Antitumor

Known as: Cancer Drug Tests, Antitumor Drug Screening Assay, Drug Test, Cancer 
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
There is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex in vivo… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2007
Highly Cited
2007
OBJECTIVES We sought to determine whether nonresponsiveness to clopidogrel as revealed by high in vitro post-treatment platelet… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
Is this relevant?
Highly Cited
2006
Highly Cited
2006
CONTEXT Adverse drug events are common and often preventable causes of medical injuries. However, timely, nationally… (More)
Is this relevant?
Review
2005
Review
2005
In vitro screening for drugs that inhibit cytochrome P450 enzymes is well established as a means for predicting potential… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
P-glycoprotein (Pgp) affects the absorption, distribution, and clearance of a variety of compounds. Thus, identification of… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • figure 2
Is this relevant?
Review
1998
Review
1998
The cytochrome P450s (CYPs) constitute a superfamily of isoforms that play an important role in the oxidative metabolism of drugs… (More)
Is this relevant?
Review
1998
Review
1998
Cytochrome P4503A (CYP3A) is importantly involved in the metabolism of many chemically diverse drugs administered to humans… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
BACKGROUND The antineoplastic compound paclitaxel (Taxol) causes an increased assembly of extraordinarily stable microtubules… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
We describe here the development and implementation of a pilot-scale, in vitro, anticancer drug screen utilizing a panel of 60… (More)
Is this relevant?