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Drug Screening Assays, Antitumor

Known as: Cancer Drug Tests, Antitumor Drug Screening Assay, Drug Test, Cancer 
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and… 
National Institutes of Health

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Tumor Cells, Culturedstandards characteristics

Papers overview

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Highly Cited
2012
Highly Cited
2012
Irinotecan Drug-Eluting Beads in the Treatment of Chemo-Naive Unresectable Colorectal Liver Metastasis with Concomitant Systemic Fluorouracil and Oxaliplatin: Results of Pharmacokinetics and Phase I…
PurposeThe primary objective of this study is to evaluate the safety, tolerance, and pharmacokinetic profile of liver-directed… 
Review
2012
Review
2012
In Vitro Evaluation of Hepatic Transporter-Mediated Clinical Drug-Drug Interactions: Hepatocyte Model Optimization and Retrospective Investigation
To assess the feasibility of using sandwich-cultured human hepatocytes (SCHHs) as a model to characterize transport kinetics for… 
Review
2005
Review
2005
Cell-based models to study hepatic drug metabolism and enzyme induction in humans
Cell-based in vitro models are invaluable tools in elucidating the pharmacokinetic profile of a drug candidate during its drug… 
Review
2002
Review
2002
Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein.
The pharmacological effects of a drug are highly dependent on the absorption, metabolism, elimination, and distribution of the… 
Highly Cited
1989
Highly Cited
1989
Ultrasound enhanced drug toxicity on Chinese hamster ovary cells in vitro.
Chinese hamster ovary cells (HA1) were exposed to therapeutic ultrasound (F = 2.025 MHz) in the presence of various drugs at… 
Review
1985
Review
1985
The use of microorganisms for the study of drug metabolism
The potential for the use of microorganisms as tools in the study of drug metabolism appears to be unlimited. The selected… 
Highly Cited
1982
Highly Cited
1982
The development and in vitro evaluation of acrylic strips and dialysis tubing for local drug delivery.
This study reports on the development of drug containing acrylic strips for delivering antimicrobial agents and compares the in… 
Highly Cited
1979
Highly Cited
1979
Correlation between benzodiazepine receptor occupation and anticonvulsant effects of diazepam
The benzodiazepines are potent anticonvulsants for a wide variety of experimental and clinical seizure disorders1,2. The… 
Highly Cited
1978
Highly Cited
1978
Carrier-mediated transport of daunorubicin, adriamycin, and rubidazone in Ehrlich ascites tumour cells.
Highly Cited
1978
Highly Cited
1978
Ultrastructure of adult rat hepatocytes cultured on floating collagen membranes.
The ultrastructure of primary hepatocytes cultured for 2 to 17 days on floating collagen membrane was evaluated. A pellet of the… 
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