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Metabolism of antimalarial sesquiterpene lactones.
Metabolism of artemisinin derivatives, which are antimalarial sesquiterpenes, appeared to lead to the production of the more polar metabolites in general. Presence of the endoperoxide moiety in theExpand
Identification of the in vivo metabolites of the antimalarial arteether by thermospray high-performance liquid chromatography/mass spectrometry.
The thermospray mass spectra of arteether and 16 of its potential metabolites all showed strong [M + NH4]+ ions and with only a few exceptions these compounds also showed spectral peaks correspondingExpand
Microbial metabolism studies of the antimalarial sesquiterpene artemisinin.
Microbial metabolism of the sesquiterpene lactone antimalarial drug artemisinin [1] was studied. Screening studies have shown a number of microorganisms capable of metabolizing artemisinin [1].Expand
Antimicrobial activity of juglone
The juice of freshly macerated unripe hulls of the black walnut (Juglans nigra) has been used for many years in folk medicine as a treatment for localized, topical fungal infections such as ringworm.Expand
Bioactive 12-oleanene triterpene and secotriterpene acids from Maytenus undata.
The aerial parts of Maytenus undata yielded four new 12-oleanene and 3,4-seco-12-oleanene triterpene acids, namely, 3-oxo-11alpha-methoxyolean-12-ene-30-oic acid (1),Expand
Antimicrobial properties of Honduran medicinal plants.
Ninety-two plants used in the traditional pharmacopoeia of the Pech and neighboring Mestizo peoples of central Honduras are reported. The results of in vitro antimicrobial screens showed that 19 ofExpand
Microbial and Mammalian Metabolism Studies on the Semisynthetic Antimalarial, Deoxoartemisinin
AbstractPurpose. Deoxoartemisinin is a semisynthetic antimalarial with potential for treatment of multiple drug resistant malaria. Metabolism studies were conducted to aid in future drug development.Expand
Triterpenes and flavonoids from Combretum leprosum
Abstract A new triterpene 3β,6β,16β-trihydroxylup-20(29)-ene, arjunolic acid, mollic acid, 3- 0 -methylquercetin and quercetrin were isolated from the leaves and roots of Combretum leprosum . TheExpand
Preparation, characterization, and antiviral activity of microbial metabolites of stemodin.
Screening studies for microbial transformation products of stemodin [2] have identified a number of microbial metabolites. Scale-up fermentation with Rhizopus arrhizus ATCC 11145 and Streptomyces sp.Expand
Thermospray mass spectroscopy/high performance liquid chromatographic identification of the metabolites formed from arteether using a rat liver microsome preparation.
Thermospray LC/MS methods with internal standardization were developed for the quantification of the antimalarial arteether and six of its metabolites at the 1-10 micrograms/ml level in liverExpand