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Metabolism of antimalarial sesquiterpene lactones.
Microbial metabolism studies of the antimalarial sesquiterpene artemisinin.
TLDR
Scale-up fermentation with Nocardia corallina and Penicillium chrysogenum has resulted in the production of two major microbial metabolites that have been characterized with the use of 2D-nmr techniques and have been identified as deoxyartemisinin and 3 alpha-hydroxydeoxyart Artemisinin.
Antimicrobial properties of Honduran medicinal plants.
Identification of the in vivo metabolites of the antimalarial arteether by thermospray high-performance liquid chromatography/mass spectrometry.
TLDR
The metabolic pathways leading to these 12 metabolites was a rather complex, multiple-step process, but most of the metabolites arose from an enzymatic oxidation at one of three sites; 3 alpha, 9 alpha, or the CH2 of the side-chain.
Antimicrobial activity of juglone
The juice of freshly macerated unripe hulls of the black walnut (Juglans nigra) has been used for many years in folk medicine as a treatment for localized, topical fungal infections such as ringworm.
Bioactive 12-oleanene triterpene and secotriterpene acids from Maytenus undata.
TLDR
The new 3,4-secotriterpene acid 20-epi-koetjapic acid (5) potently inhibited rat neonatal brain microglia phorbol ester-stimulated thromboxane B(2) and superoxide anion (IC(50) = 1.9 microM) generation.
Microbial and Mammalian Metabolism Studies on the Semisynthetic Antimalarial, Deoxoartemisinin
TLDR
Deoxoartemisinin was metabolized to three microbial metabolites, which showed the presence of two metabolites in the plasma, one of which was the same as the microbial metabolite.
Microbial metabolites of ophiobolin A and antimicrobial evaluation of ophiobolins.
TLDR
The structures of these metabolites were established by spectroscopic methods and by comparison of the spectral data with those of the starting material as well as the antimicrobial activity of the ophiobolins.
Preparation, characterization, and antiviral activity of microbial metabolites of stemodin.
TLDR
Scale-up fermentation with Rhizopus arrhizus ATCC 11145 and Streptomyces NRRL 5691 have resulted in the production of five metabolites that have been characterized with the use of 2D nmr and X-ray techniques, and the antiviral activity and cytotoxicity of the isolated metabolites have been evaluated.
Thermospray mass spectroscopy/high performance liquid chromatographic identification of the metabolites formed from arteether using a rat liver microsome preparation.
TLDR
The thermospray mass spectra of arteether and most of its metabolites exhibited strong [M + NH4]+ and [M - OR]+ peaks arising from the molecular ion adduct and the loss of the alkoxy or hydroxy group of the side chain.
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