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Dothiepin

Known as: trans-dothiepin, Dothiepin [Chemical/Ingredient], 1-Propanamine, 3-dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl- 
A tricyclic antidepressant with some tranquilizing action.
National Institutes of Health

Related topics

Related topics

15 relations

Broader (2)

Adrenergic Uptake InhibitorsTricyclic Antidepressive Agents

Narrower (5)

Dothiepin HydrochlorideProthiadenmedosulepinenorthiaden
Dothiepin sulfoxide:MCnc:Pt:Ser/Plas:QnIn Bloodagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
On the inter-instrument and the inter-laboratory transferability of a tandem mass spectral reference library. 3. Focus on ion trap and upfront CID.
Mass spectral libraries represent versatile tools for the identification of small bioorganic molecules. Libraries based on… 
Highly Cited
2004
Highly Cited
2004
Screening and semi-quantitative analysis of post mortem blood for basic drugs using gas chromatography/ion trap mass spectrometry.
2002
2002
Effects of 5 weeks of administration of fluoxetine and dothiepin in normal volunteers on sleep, daytime sedation, psychomotor performance and mood
This was a placebo-controlled, double-blind randomized crossover study of long-term (5 weeks) administration of fluoxetine (20 mg… 
Highly Cited
2001
Highly Cited
2001
Screening for Detection of New Antidepressants, Neuroleptics, Hypnotics, and Their Metabolites in Urine by GC-MS Developed Using Rat Liver Microsomes
A gas chromatography–mass spectrometry (GC-MS) procedure for the detection of new antidepressants, neuroleptics, hypnotics, and… 
2000
2000
Sleep and daytime sleepiness the next day following single night-time dose of fluvoxamine, dothiepin and placebo in normal volunteers
To explore the effects of sedating and non-sedating antidepressants, we conducted a placebo-controlled, double-blind cross-over… 
1993
1993
Dual ultraviolet wavelength high-performance liquid chromatographic method for the forensic or clinical analysis of seventeen antidepressants and some selected metabolites.
1982
1982
WILL AMITRIPTYLINE PREVENT THE "CHEESE" REACTION OF MONOAMINE-OXIDASE INHIBITORS?
1981
1981
Clinical Interpretation of Pharmacokinetic Data on Dothiepin Hydrochloride (Dosulepin, Prothiaden)
Pharmacokinetic and pharmacodynamic studies on dothiepin can be divided into three main areas: radiolabelled studies, single dose… 
1980
1980
A Double-Blind Comparison of Dothiepin and Amitriptyline in Patients with Primary Affective Disorder: Serum Levels and Clinical Response
Summary In a double-blind parallel group study, thirty-two patients suffering from a primary affective disorder received either… 
1974
1974
A General Practitioner Study of Dothiepin and Amitriptyline
Forty-one patients completed a four-week double-blind study comparing dothiepin and amitriptyline. The anti-depressant effect of… 
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