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Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
TLDR
Psilocybin caused a significant decrease in the positive coupling between the mPFC and PCC, which strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition.
Neural correlates of the LSD experience revealed by multimodal neuroimaging
TLDR
Three complementary neuroimaging techniques, implemented during resting state conditions, revealed marked changes in brain activity after LSD that correlated strongly with its characteristic psychological effects, contributing important new insights into the characteristic hallucinatory and consciousness-altering properties of psychedelics.
The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs
TLDR
It is argued that the defining feature of “primary states” is elevated entropy in certain aspects of brain function, such as the repertoire of functional connectivity motifs that form and fragment across time, and that this entropy suppression furnishes normal waking consciousness with a constrained quality and associated metacognitive functions, including reality-testing and self-awareness.
Amphetamine, past and present – a pharmacological and clinical perspective
TLDR
The review charts advances in pharmaceutical development from the introduction of once-daily formulations of amphetamine through to lisdexamfetamine, which is the first d-amphetamine prodrug approved for the management of ADHD in children, adolescents and adults.
Consensus statement on generalized anxiety disorder from the International Consensus Group on Depression and Anxiety.
TLDR
GAD is the most common anxiety disorder in primary care and is highly debilitating, and it is frequently comorbid with depression and other anxiety disorders, which exacerbates functional impairment.
Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: A revision of the 2005 guidelines from the British Association for
This revision of the 2005 British Association for Psychopharmacology guidelines for the evidence-based pharmacological treatment of anxiety disorders provides an update on key steps in diagnosis and
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