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The Digitalis Investigation Group (DIG) trial reported that digoxin provided no overall mortality benefit and only a… Expand BACKGROUND
The Digitalis Investigation Group trial reported that treatment with digoxin did not decrease overall mortality among… Expand BACKGROUND
Implantable left ventricular assist devices have benefited patients with end-stage heart failure as a bridge to… Expand BACKGROUND AND METHODS
Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663… Expand Recent data point to the contribution of P-glycoprotein (P-gp) to digoxin elimination. On the basis of clinical observations of… Expand BACKGROUND
The role of cardiac glycosides in treating patients with chronic heart failure and normal sinus rhythm remains… Expand BACKGROUND
Controlled clinical trials have shown that beta-blockers can produce hemodynamic and symptomatic improvement in… Expand We have previously shown that absence of the mouse mdr1a (also called mdr3) P-glycoprotein in mdr1a (-/-) "knockout" mice has a… Expand BACKGROUND
Although digoxin is effective in the treatment of patients with chronic heart failure who are receiving diuretic… Expand A biosynthetic antibody binding site, which incorporated the variable domains of anti-digoxin monoclonal antibody 26-10 in a… Expand