Digoxin

Known as: Digoxigenin-tridigitoxosid, digoxin substance, 12beta-Hydroxydigitoxin 
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
CD4+ T helper lymphocytes that express interleukin-17 (TH17 cells) have critical roles in mouse models of autoimmunity, and there… (More)
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Highly Cited
2008
Highly Cited
2008
A library of drugs that are in clinical trials or use was screened for inhibitors of hypoxia-inducible factor 1 (HIF-1). Twenty… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND About half of the 5 million heart failure patients in the United States have diastolic heart failure (clinical heart… (More)
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Highly Cited
2003
Highly Cited
2003
CONTEXT The Digitalis Investigation Group (DIG) trial reported that digoxin provided no overall mortality benefit and only a… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The Digitalis Investigation Group trial reported that treatment with digoxin did not decrease overall mortality among… (More)
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Highly Cited
2000
Highly Cited
2000
To evaluate whether alterations in the multidrug-resistance (MDR)-1 gene correlate with intestinal MDR-1 expression and uptake of… (More)
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Highly Cited
1999
Highly Cited
1999
Recent data point to the contribution of P-glycoprotein (P-gp) to digoxin elimination. On the basis of clinical observations of… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND AND METHODS Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Although quinidine is known to elevate plasma digoxin concentrations, the mechanism underlying this interaction is not… (More)
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Highly Cited
1988
Highly Cited
1988
A biosynthetic antibody binding site, which incorporated the variable domains of anti-digoxin monoclonal antibody 26-10 in a… (More)
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