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Digoxin

Known as: Digoxigenin-tridigitoxosid, digoxin substance, 12beta-Hydroxydigitoxin 
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive… Expand
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
CONTEXT The Digitalis Investigation Group (DIG) trial reported that digoxin provided no overall mortality benefit and only a… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The Digitalis Investigation Group trial reported that treatment with digoxin did not decrease overall mortality among… Expand
Highly Cited
2001
Highly Cited
2001
BACKGROUND Implantable left ventricular assist devices have benefited patients with end-stage heart failure as a bridge to… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND AND METHODS Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663… Expand
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Highly Cited
1999
Highly Cited
1999
Recent data point to the contribution of P-glycoprotein (P-gp) to digoxin elimination. On the basis of clinical observations of… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND The role of cardiac glycosides in treating patients with chronic heart failure and normal sinus rhythm remains… Expand
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Controlled clinical trials have shown that beta-blockers can produce hemodynamic and symptomatic improvement in… Expand
Highly Cited
1995
Highly Cited
1995
We have previously shown that absence of the mouse mdr1a (also called mdr3) P-glycoprotein in mdr1a (-/-) "knockout" mice has a… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Although digoxin is effective in the treatment of patients with chronic heart failure who are receiving diuretic… Expand
Highly Cited
1988
Highly Cited
1988
A biosynthetic antibody binding site, which incorporated the variable domains of anti-digoxin monoclonal antibody 26-10 in a… Expand