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Digoxin

Known as: Digoxigenin-tridigitoxosid, digoxin substance, 12beta-Hydroxydigitoxin 
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals… Expand
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Highly Cited
2003
Highly Cited
2003
CONTEXT The Digitalis Investigation Group (DIG) trial reported that digoxin provided no overall mortality benefit and only a… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Implantable left ventricular assist devices have benefited patients with end-stage heart failure as a bridge to… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND AND METHODS Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663… Expand
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Highly Cited
1999
Highly Cited
1999
Recent data point to the contribution of P-glycoprotein (P-gp) to digoxin elimination. On the basis of clinical observations of… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND The role of cardiac glycosides in treating patients with chronic heart failure and normal sinus rhythm remains… Expand
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Controlled clinical trials have shown that beta-blockers can produce hemodynamic and symptomatic improvement in… Expand
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Highly Cited
1995
Highly Cited
1995
We have previously shown that absence of the mouse mdr1a (also called mdr3) P-glycoprotein in mdr1a (-/-) "knockout" mice has a… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Although digoxin is effective in the treatment of patients with chronic heart failure who are receiving diuretic… Expand
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Highly Cited
1988
Highly Cited
1988
A biosynthetic antibody binding site, which incorporated the variable domains of anti-digoxin monoclonal antibody 26-10 in a… Expand
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