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The effect of digoxin on mortality and morbidity in patients with heart failure.
BACKGROUND The role of cardiac glycosides in treating patients with chronic heart failure and normal sinus rhythm remains controversial. We studied the effect of digoxin on mortality andExpand
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The effect of limited handrail support on total treadmill time and the prediction of vo2 max
Holding onto the front handrail during treadmill testing significantly increases total treadmill time (TT) and predicted VO2 max when compared with tests without front handrail support. By limitingExpand
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Effects of anesthetics containing epinephrine on catecholamine levels during periodontal surgery.
Nine stable cardiovascular disease patients were evaluated in a double-blind cross-over trial during periodontal surgery using 2% lidocaine with epinephrine 1:100,000 or lidocaine alone. In theExpand
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Rationale, design, implementation, and baseline characteristics of patients in the DIG trial: a large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure.
This article provides a detailed overview of the rationale for key aspects of the protocol of the Digitalis Investigation Group (DIG) trial. It also highlights unusual aspects of the studyExpand
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Superior bioavailability of digoxin solution in capsules
The bioavailability of various formulations of digoxin was assessed after single and multiple doses in a series of crossover studies in human volunteers. Digoxin tablets that were 97% dissolved in 1Expand
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Improving diagnostic accuracy of the exercise test by combining R-wave changes with duration of ST segment depression in a simplified index.
To enhance the reliability of the exercise test in diagnosing both overall coronary artery disease and multivessel coronary artery disease, a discriminant function was obtained by means of stepwiseExpand
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Comparison of lorcainide and quinidine in the treatment of ventricular ectopy.
Lorcainide, a new type I antiarrhythmic agent, was compared to quinidine in respect to antiarrhythmic efficacy and clinical safety. Thirteen subjects completed an open, randomized, crossover studyExpand
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Intracardiac right-to-left shunting following cardiac surgery.
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