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Dickkopf-Related Protein 4

Known as: Dickkopf 4, Dickkopf Related Protei-42, hDkk-4 
Dickkopf-related protein 4 (224 aa, ~25 kDa) is encoded by the human DKK4 gene. This protein is involved in the negative regulation of Wnt signaling.
National Institutes of Health

Related topics

Related topics

8 relations
DKK4 geneIntercellular Communication ProcessSignal TransductionSignal Transduction Inhibition

Papers overview

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2018
2018
Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins
Dickkopf (Dkk) family proteins are important regulators of Wnt signaling pathways, which play key roles in many essential… 
Highly Cited
2013
Highly Cited
2013
A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells
IntroductionIncreased expression of the proinflammatory cytokine TNF-α in intervertebral discs (IVDs) leads to inflammation… 
2012
2012
Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma
Deregulation of Wnt/β-catenin pathway is a hallmark of major gastrointestinal cancers including hepatocellular carcinoma (HCC… 
2010
2010
Dkk4 and Eda Regulate Distinctive Developmental Mechanisms for Subtypes of Mouse Hair
The mouse hair coat comprises protective “primary” and thermo-regulatory “secondary” hairs. Primary hair formation is… 
Highly Cited
2009
Highly Cited
2009
DICKKOPF‐4 and ‐2 genes are upregulated in human colorectal cancer
To comprehensively screen for genetic events underlying colorectal cancer, we performed suppression subtraction hybridization… 
Highly Cited
2008
Highly Cited
2008
DICKKOPF-4 is induced by TCF/β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α,25-dihydroxyvitamin D3
Aberrant activation of the Wnt/β-catenin signaling pathway is a hallmark of colon cancer. We show that the Wnt antagonist… 
Review
2008
Review
2008
Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes.
Colorectal cancer is a major health problem worldwide. Aberrant activation of the Wingless-type mouse mammary tumour virus… 
2008
2008
Positional Pathway Screen of wnt Signaling Genes in Schizophrenia: Association with DKK4
Highly Cited
2007
Highly Cited
2007
The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis.
Highly Cited
1999
Highly Cited
1999
Functional and structural diversity of the human Dickkopf gene family.
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