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Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.
- N. Enomoto, I. Sakuma, +7 authors C. Sato
- Biology, Medicine
- The New England journal of medicine
- 11 January 1996
BACKGROUND A region associated with sensitivity to interferon has been identified in the nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. The region spans amino acid residues… Expand
A first case of meningitis/encephalitis associated with SARS-Coronavirus-2
- T. Moriguchi, N. Harii, +26 authors S. Shimada
- International Journal of Infectious Diseases
- 3 April 2020
Abstract Novel coronavirus (SARS-Coronavirus-2:SARS-CoV-2) which emerged in Wuhan, China, has spread to multiple countries rapidly. We report the first case of meningitis associated with… Expand
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
International standardization and coordination of the nomenclature of variants of hepatitis C virus (HCV) is increasingly needed as more is discovered about the scale of HCV‐related liver disease and… Expand
Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.
- N. Enomoto, I. Sakuma, +6 authors C. Sato
- Biology, Medicine
- The Journal of clinical investigation
- 1 July 1995
We have previously demonstrated that sensitivity to interferon is different among hepatitis C virus (HCV) quasispecies simultaneously detected in same individuals and that interferon-resistant HCV… Expand
Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins.
BACKGROUND & AIMS Cyclosporin A specifically suppresses hepatitis C virus (HCV) replication in vitro at clinically achievable concentrations. In this study, we investigated the mechanisms of action… Expand
Imaging study of early hepatocellular carcinoma: usefulness of gadoxetic acid-enhanced MR imaging.
PURPOSE To describe imaging findings of early hepatocellular carcinoma (HCC) at gadoxetic acid-enhanced magnetic resonance (MR) imaging, dynamic contrast material-enhanced computed tomography (CT),… Expand
EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus
- Mitsuhiko Hanawa, S. Suzuki, +4 authors Akishi Ooi
- Medicine, Biology
- International journal of cancer
- 1 March 2006
Overexpression of epidermal growth factor receptor (EGFR) is observed in many cancers, sometimes accompanied by gene amplification. Recently, several clinical therapies targeting EGFR were developed,… Expand
The glutathione precursor L‐2‐oxothiazolidine‐4‐carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat
L ‐2‐oxothiazolidine‐4‐carboxylic acid (OTC) is a cysteine prodrug that maintains glutathione in tissues. Here, its effect on alcohol‐induced liver injury in an enteral alcohol feeding model was… Expand
Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin.
BACKGROUND & AIMS Ethanol causes both tolerance and sensitization of Kupffer cells. This study was designed to evaluate temporal effects of ethanol in an attempt to understand this paradox. METHODS… Expand
Specific inhibition of hepatitis C virus replication by cyclosporin A.
- M. Nakagawa, N. Sakamoto, +10 authors M. Watanabe
- Medicine, Biology
- Biochemical and biophysical research…
- 2 January 2004
The difficulty in eradicating hepatitis C virus (HCV) infection is attributable to the limited treatment options against the virus. Recently, cyclosporin A (CsA), a widely used immunosuppressive… Expand