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Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.
BACKGROUND A region associated with sensitivity to interferon has been identified in the nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. The region spans amino acid residuesExpand
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A first case of meningitis/encephalitis associated with SARS-Coronavirus-2
Abstract Novel coronavirus (SARS-Coronavirus-2:SARS-CoV-2) which emerged in Wuhan, China, has spread to multiple countries rapidly. We report the first case of meningitis associated withExpand
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Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
International standardization and coordination of the nomenclature of variants of hepatitis C virus (HCV) is increasingly needed as more is discovered about the scale of HCV‐related liver disease andExpand
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Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.
We have previously demonstrated that sensitivity to interferon is different among hepatitis C virus (HCV) quasispecies simultaneously detected in same individuals and that interferon-resistant HCVExpand
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Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins.
BACKGROUND & AIMS Cyclosporin A specifically suppresses hepatitis C virus (HCV) replication in vitro at clinically achievable concentrations. In this study, we investigated the mechanisms of actionExpand
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Imaging study of early hepatocellular carcinoma: usefulness of gadoxetic acid-enhanced MR imaging.
PURPOSE To describe imaging findings of early hepatocellular carcinoma (HCC) at gadoxetic acid-enhanced magnetic resonance (MR) imaging, dynamic contrast material-enhanced computed tomography (CT),Expand
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EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus
Overexpression of epidermal growth factor receptor (EGFR) is observed in many cancers, sometimes accompanied by gene amplification. Recently, several clinical therapies targeting EGFR were developed,Expand
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The glutathione precursor L‐2‐oxothiazolidine‐4‐carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat
L ‐2‐oxothiazolidine‐4‐carboxylic acid (OTC) is a cysteine prodrug that maintains glutathione in tissues. Here, its effect on alcohol‐induced liver injury in an enteral alcohol feeding model wasExpand
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Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin.
BACKGROUND & AIMS Ethanol causes both tolerance and sensitization of Kupffer cells. This study was designed to evaluate temporal effects of ethanol in an attempt to understand this paradox. METHODSExpand
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Specific inhibition of hepatitis C virus replication by cyclosporin A.
The difficulty in eradicating hepatitis C virus (HCV) infection is attributable to the limited treatment options against the virus. Recently, cyclosporin A (CsA), a widely used immunosuppressiveExpand
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