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Dextrorphan

Known as: (+-)-17-Methylmorphinan-3-ol, Dextrorphan [Chemical/Ingredient], Morphinan-3-ol, 17-methyl-, (9alpha,13alpha,14alpha)- 
Dextro form of levorphanol. It acts as a noncompetitive NMDA receptor antagonist, among other effects, and has been proposed as a neuroprotective… 
National Institutes of Health

Related topics

Related topics

10 relations
Dextrorphan:MCnc:Pt:Urine:QnIn Bloodagonistsanalogs & derivatives

Broader (2)

Excitatory Amino Acid AntagonistsNeuroprotective Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
The role of CYP 2 D 6 in primary and secondary oxidative metabolism of dextromethorphan : in vitro studies using human liver microsomes
1 The enzyme kinetics of dextromethorphan O-demethylation in liver microsomes from three extensive metabolisers (EM) with respect… 
2002
2002
TRIMETHOPRIM AND SULFAMETHOXAZOLE ARE SELECTIVE INHIBITORS OF CYP 2 C 8 AND CYP 2 C 9 , RESPECTIVELY
To evaluate the inhibitory effects of trimethoprim and sulfamethoxazole on cytochrome P450 (P450) isoforms, selective marker… 
2001
2001
IN VITRO INHIBITION OF CYTOCHROME P 450 ENZYMES IN HUMAN LIVER MICROSOMES BY A POTENT CYP 2 A 6 INHIBITOR , TRANS-2-PHENYLCYCLOPROPYLAMINE ( TRANYLCYPROMINE ) , AND ITS NONAMINE ANALOG
Currently, there are no selective, well characterized inhibitors for CYP2A6. Therefore, the effects of trans-(6)-2… 
1999
1999
Oxybutynin enhances the metabolism of clomipramine and dextrorphan possibly by induction of a cytochrome P450 isoenzyme.
1993
1993
Identification with liquid chromatography-ionspray mass spectrometry of the metabolites of the enantiomers N-methyl dextrorphan and N-methyl levorphanol after rat liver perfusion.
To gather more information on stereochemical factors in the hepatic disposition of organic cations, mass spectrometry coupled to… 
Highly Cited
1992
Highly Cited
1992
Dextromethorphan and Mephenytoin Phenotyping of Patients Treated with Thioridazine or Amitriptyline
The metabolism of most tricyclic antidepressants and some phenothiazine neuroleptics is under the genetic control of hepatic… 
1978
1978
Sex differences in plasma half-life of dextrorphan in rats administered dextromethorphan.
Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan. Upon oral administration of… 
1978
1978
Structural requirements in the reaction of morphine uridine diphosphate glucuronyltransferase with opioid substances.
The influence of the 3-hydroxyl and N-alkyl groups in the reactivity of narcotic compounds with morphine UDP… 
1978
1978
Effects of opiates on cAMP in homogenates and slices of rat striata.
In slices of rat striata, incubated in a depolarizing medium (53 mM K+), morphine decreased by concentration of cAMP even in… 
1975
1975
Comparative effects of opiate agonists methadone, levorphanol, and their isomers on the release of cortical ACh in vivo and in vitro.
The effect of analgesically active opiate agonists dl-methadone, levorphanol, and their less active forms d-methadone and… 
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