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Dextrorphan

Known as: (+-)-17-Methylmorphinan-3-ol, Dextrorphan [Chemical/Ingredient], Morphinan-3-ol, 17-methyl-, (9alpha,13alpha,14alpha)- 
Dextro form of levorphanol. It acts as a noncompetitive NMDA receptor antagonist, among other effects, and has been proposed as a neuroprotective… 
National Institutes of Health

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10 relations
Dextrorphan:MCnc:Pt:Urine:QnIn Bloodagonistsanalogs & derivatives

Broader (2)

Excitatory Amino Acid AntagonistsNeuroprotective Agents

Papers overview

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2015
2015
Diabetes: Dextromethorphan stimulates insulin secretion from pancreatic β cells—a new role for an old drug?
Diabetes: Dextromethorphan stimulates insulin secretion from pancreatic β cells—a new role for an old drug? 
2004
2004
Simultaneous determination of dextrorphan and guaifenesin in human plasma by HPLC
A new HPLC method with fluorescence detector was developed and validated for the simultaneous determination of dextrorphan and… 
2001
2001
IN VITRO INHIBITION OF CYTOCHROME P 450 ENZYMES IN HUMAN LIVER MICROSOMES BY A POTENT CYP 2 A 6 INHIBITOR , TRANS-2-PHENYLCYCLOPROPYLAMINE ( TRANYLCYPROMINE ) , AND ITS NONAMINE ANALOG
Currently, there are no selective, well characterized inhibitors for CYP2A6. Therefore, the effects of trans-(6)-2… 
Review
1995
Review
1995
Safety, tolerability and pharmacokinetics of the N-methyl-D-aspartate antagonist Ro-01-6794/706 in patients with acute ischemic stroke. The Dextrorphan Study Group and Hoffmann-La Roche.
Dextrorphan HCl (Ro 01-6794/706) is an NMDA receptor antagonist with clinical potential for administration in an elderly… 
1993
1993
Identification with liquid chromatography-ionspray mass spectrometry of the metabolites of the enantiomers N-methyl dextrorphan and N-methyl levorphanol after rat liver perfusion.
To gather more information on stereochemical factors in the hepatic disposition of organic cations, mass spectrometry coupled to… 
1978
1978
Sex differences in plasma half-life of dextrorphan in rats administered dextromethorphan.
Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan. Upon oral administration of… 
1978
1978
Structural requirements in the reaction of morphine uridine diphosphate glucuronyltransferase with opioid substances.
The influence of the 3-hydroxyl and N-alkyl groups in the reactivity of narcotic compounds with morphine UDP… 
1978
1978
Effects of opiates on cAMP in homogenates and slices of rat striata.
In slices of rat striata, incubated in a depolarizing medium (53 mM K+), morphine decreased by concentration of cAMP even in… 
1977
1977
Differential effects of opiates on the incorporation of [14C] thiamine in the central nervous system of the rat
Opiate agonist (morphine), pure antagonist (naloxone), mixed agonist-antagonist (nalorphine) and analgesically inactive… 
1975
1975
Comparative effects of opiate agonists methadone, levorphanol, and their isomers on the release of cortical ACh in vivo and in vitro.
The effect of analgesically active opiate agonists dl-methadone, levorphanol, and their less active forms d-methadone and…