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DUSP1 protein, human

Known as: Mitogen-Activated Protein Kinase Phosphatase 1, MKP-1 protein, human, DUSP1 
Dual specificity protein phosphatase 1 (367 aa, ~39 kDa) is encoded by the human DUSP1 gene. This protein plays a role in the dephosphorylation of… 
National Institutes of Health

Related topics

Related topics

26 relations
CD40L Signaling PathwayCell ProliferationCellular Stress ResponseDUSP1 gene

Broader (1)

Dual Specificity Phosphatase 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Cluster Analysis of Obesity and Asthma Phenotypes
Background Asthma is a heterogeneous disease with variability among patients in characteristics such as lung function, symptoms… 
Review
2008
Review
2008
Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer
Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1, DUSP1, ERP, CL100, HVH1, PTPN10, and 3CH134… 
Highly Cited
2002
Highly Cited
2002
Restraint of Proinflammatory Cytokine Biosynthesis by Mitogen-Activated Protein Kinase Phosphatase-1 in Lipopolysaccharide-Stimulated Macrophages
Exposure of macrophages to LPS elicits the production of proinflammatory cytokines, such as TNF-α, through complex signaling… 
Highly Cited
2001
Highly Cited
2001
Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP‐1
Glucocorticoids inhibit the proinflammatory activities of transcription factors such as AP‐1 and NF‐κB as well as that of diverse… 
Highly Cited
2001
Highly Cited
2001
Distinct Binding Determinants for ERK2/p38α and JNK MAP Kinases Mediate Catalytic Activation and Substrate Selectivity of MAP Kinase Phosphatase-1* 210
Mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1/CL100) is an inducible nuclear dual specificity protein phosphatase… 
Highly Cited
1999
Highly Cited
1999
From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.
Overexpression of the HER2/Neu protooncogene has been linked to the progression of breast cancer. Here we demonstrate that the… 
Highly Cited
1997
Highly Cited
1997
Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase.
Angiotensin II type 2 (AT2) receptors are involved in the inhibition of cell proliferation as well as in apoptosis and neuronal… 
Highly Cited
1996
Highly Cited
1996
Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis.
Many mitogens and human oncogenes activate extracellular regulated kinases (ERKs), which in turn convey proliferation signals… 
Highly Cited
1995
Highly Cited
1995
Mitogen-activated Protein (MAP) Kinase Is Regulated by the MAP Kinase Phosphatase (MKP-1) in Vascular Smooth Muscle Cells
Angiotensin II stimulates hypertrophic growth of vascular smooth muscle cells (VSMC) and activates many growth-promoting kinases… 
Highly Cited
1995
Highly Cited
1995
Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts.
MAP kinase (mitogen activated protein kinase) represents a ubiquitously expressed family of kinases whose long term activation… 
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