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Dual Specificity Phosphatase 1

Known as: MKP-1 Phosphatase, Map Kinase Phosphatase 1, 3CH134 Phosphatase 
A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It… 
National Institutes of Health

Related topics

Related topics

13 relations
DUSP1 geneIn BloodMitogen-Activated Protein Kinase PhosphatasesProcess of secretion

Narrower (4)

DUSP1 protein, humanDmel-MKP protein, DrosophilaDusp1 protein, ratPmp1 protein, S pombe

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Progesterone and the Repression of Myometrial Inflammation: The Roles of MKP-1 and the AP-1 System.
Progesterone (P4) maintains uterine quiescence during pregnancy and its functional withdrawal is associated with increased… 
2014
2014
The Pseudophosphatase MK-STYX Induces Neurite-Like Outgrowths in PC12 Cells
The rat pheochromocytoma PC12 cell line is a widely used system to study neuronal differentiation for which sustained activation… 
2014
2014
MKP-1 signaling events are required for early osteoclastogenesis in lineage defined progenitor populations by disrupting RANKL-induced NFATc1 nuclear translocation.
2012
2012
Hypotonic stress upregulates β- and γ-ENaC expression through suppression of ERK by inducing MKP-1.
We investigated a physiological role for ERK, a member of the MAPK family, in the hypotonic stimulation of epithelial Na… 
2011
2011
Down-regulation of Cytokine-induced Interleukin-8 Requires Inhibition of p38 Mitogen-activated Protein Kinase (MAPK) via MAPK Phosphatase 1-dependent and -independent Mechanisms*
Down-regulation of overabundant interleukin (IL)-8 present in cystic fibrosis (CF) airways could ease excessive neutrophil burden… 
2007
2007
Dexamethasone suppresses interleukin-1beta-induced human beta-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-kappaB transcriptional factor in A549 cells.
Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide that plays an important role in innate immunity… 
2007
2007
Renal p38 MAP kinase activity in experimental diabetes
Renal cell activity of p38 mitogen-activated protein kinase (p38) is increased in the diabetic milieu. p38 mediates signals… 
2005
2005
MKP-8, a novel MAPK phosphatase that inhibits p38 kinase.
Highly Cited
2001
Highly Cited
2001
Role of extracellular signal‐regulated protein kinase cascade in macrophage killing of Candida albicans
The pathogenic yeast Candida albicans and its derivedmolecules stimulate a wide range of macrophage secretory functions andmay… 
Highly Cited
1998
Highly Cited
1998
Inhibition of the Expression of Mitogen-activated Protein Phosphatase-1 Potentiates Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells*
Previously we showed that rat mesangial cells are normally resistant to tumor necrosis factor-α (TNF-α)-induced apoptosis. They… 
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