Dual Specificity Phosphatase 1

Known as: MKP-1 Phosphatase, Map Kinase Phosphatase 1, 3CH134 Phosphatase 
A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It… (More)
National Institutes of Health

Related topics

Related topics

13 relations
DUSP1 geneIn BloodMitogen-Activated Protein Kinase PhosphatasesProcess of secretion
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Narrower (4)

DUSP1 protein, humanDmel-MKP protein, DrosophilaDusp1 protein, ratPmp1 protein, S pombe

Papers overview

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2011
2011
CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection.
The macrophage-expressed CD40 regulates immune responses to Leishmania major infection by reciprocal signaling through p38 MAPK… (More)
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Review
2010
Review
2010
The extended PP1 toolkit: designed to create specificity.
Protein Ser/Thr phosphatase-1 (PP1) catalyzes the majority of eukaryotic protein dephosphorylation reactions in a highly… (More)
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Highly Cited
2006
Highly Cited
2006
Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
Activation of the mitogen-activated protein kinase (MAPK) cascade after Toll-like receptor stimulation enables innate immune… (More)
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Highly Cited
2006
Highly Cited
2006
Essential role of MAPK phosphatase-1 in the negative control of innate immune responses.
TLR-induced innate immunity and inflammation are mediated by signaling cascades leading to activation of the MAPK family of Ser… (More)
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Highly Cited
2006
Highly Cited
2006
The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells.
PURPOSE Excessive activity of the transcription factors known as signal transducers and activators of transcription (STAT… (More)
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Highly Cited
2004
Highly Cited
2004
Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase.
The p38 and JNK classes of mitogen-activated protein kinases (MAPKs) have evolutionarily conserved roles in the control of… (More)
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Highly Cited
2004
Highly Cited
2004
The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.
Mitogen-activated protein kinases (MAPKs) are integral to the mechanisms by which cells respond to physiological stimuli and to a… (More)
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2001
2001
Role of extracellular signal-regulated protein kinase cascade in macrophage killing of Candida albicans.
The pathogenic yeast Candida albicans and its derived molecules stimulate a wide range of macrophage secretory functions and may… (More)
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2001
2001
The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing…
The G-CSF receptor transduces signals that regulate the proliferation, differentiation, and survival of myeloid cells. A subgroup… (More)
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1998
1998
Inhibition of the expression of mitogen-activated protein phosphatase-1 potentiates apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells.
Previously we showed that rat mesangial cells are normally resistant to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis… (More)
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