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Dual Specificity Phosphatase 1

Known as: MKP-1 Phosphatase, Map Kinase Phosphatase 1, 3CH134 Phosphatase 
A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It… Expand
National Institutes of Health

Related topics

Related topics

13 relations
DUSP1 geneIn BloodMitogen-Activated Protein Kinase PhosphatasesProcess of secretion
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Narrower (4)

DUSP1 protein, humanDmel-MKP protein, DrosophilaDusp1 protein, ratPmp1 protein, S pombe

Papers overview

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Review
2010
Review
2010
The extended PP1 toolkit: designed to create specificity.
Protein Ser/Thr phosphatase-1 (PP1) catalyzes the majority of eukaryotic protein dephosphorylation reactions in a highly… Expand
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Highly Cited
2007
Highly Cited
2007
Conserved Regulation of MAP Kinase Expression by PUF RNA-Binding Proteins
Mitogen-activated protein kinase (MAPK) and PUF (for Pumilio and FBF [fem-3 binding factor]) RNA-binding proteins control many… Expand
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Highly Cited
2006
Highly Cited
2006
Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
Activation of the mitogen-activated protein kinase (MAPK) cascade after Toll-like receptor stimulation enables innate immune… Expand
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Highly Cited
2006
Highly Cited
2006
Essential Role of MAPK Phosphatase-1 in the Negative Control of Innate Immune Responses
TLR-induced innate immunity and inflammation are mediated by signaling cascades leading to activation of the MAPK family of Ser… Expand
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Highly Cited
2004
Highly Cited
2004
Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase.
The p38 and JNK classes of mitogen-activated protein kinases (MAPKs) have evolutionarily conserved roles in the control of… Expand
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Highly Cited
2004
Highly Cited
2004
The Caenorhabditis elegans MAPK phosphatase VHP‐1 mediates a novel JNK‐like signaling pathway in stress response
Mitogen‐activated protein kinases (MAPKs) are integral to the mechanisms by which cells respond to physiological stimuli and to a… Expand
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Highly Cited
2000
Highly Cited
2000
High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation.
Our laboratory has recently demonstrated a role for the phosphatidylinositol 3-kinase-mediated inducible NO synthase (iNOS… Expand
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Highly Cited
1999
Highly Cited
1999
Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression Is Induced by Low Oxygen Conditions Found in Solid Tumor Microenvironments
Pathophysiological hypoxia is an important modulator of gene expression in solid tumors and other pathologic conditions. We… Expand
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Highly Cited
1999
Highly Cited
1999
Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation
The crystal structure of the catalytic domain from the MAPK phosphatase Pyst1 (Pyst1–CD) has been determined at 2.35 Å. The… Expand
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Highly Cited
1998
Highly Cited
1998
Inhibition of the Expression of Mitogen-activated Protein Phosphatase-1 Potentiates Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells*
Previously we showed that rat mesangial cells are normally resistant to tumor necrosis factor-α (TNF-α)-induced apoptosis. They… Expand
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