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Dual Specificity Phosphatase 1

Known as: MKP-1 Phosphatase, Map Kinase Phosphatase 1, 3CH134 Phosphatase 
A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It… 
National Institutes of Health

Related topics

Related topics

13 relations
DUSP1 geneIn BloodMitogen-Activated Protein Kinase PhosphatasesProcess of secretion

Narrower (4)

DUSP1 protein, humanDmel-MKP protein, DrosophilaDusp1 protein, ratPmp1 protein, S pombe

Papers overview

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2014
2014
The Pseudophosphatase MK-STYX Induces Neurite-Like Outgrowths in PC12 Cells
The rat pheochromocytoma PC12 cell line is a widely used system to study neuronal differentiation for which sustained activation… 
2014
2014
MKP-1 signaling events are required for early osteoclastogenesis in lineage defined progenitor populations by disrupting RANKL-induced NFATc1 nuclear translocation.
2011
2011
Down-regulation of Cytokine-induced Interleukin-8 Requires Inhibition of p38 Mitogen-activated Protein Kinase (MAPK) via MAPK Phosphatase 1-dependent and -independent Mechanisms*
Down-regulation of overabundant interleukin (IL)-8 present in cystic fibrosis (CF) airways could ease excessive neutrophil burden… 
2009
2009
Regional Expression of MAPK Phosphatase 1 (MKP1, DUSP1) Is Altered in Prone vs. Supine Overdistension Lung Injury.
2008
2008
SH2-Inositol Phosphatase 1 Negatively Influences Early Megakaryocyte Progenitors
Background The SH2-containing-5′inositol phosphatase-1 (SHIP) influences signals downstream of cytokine/chemokine receptors that… 
2007
2007
Dexamethasone suppresses interleukin-1beta-induced human beta-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-kappaB transcriptional factor in A549 cells.
Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide that plays an important role in innate immunity… 
2004
2004
Regulation of c-Jun N-terminal kinase and p38 kinase pathways in endothelial cells.
The rapid and transient induction of E-selectin gene expression by inflammatory tumor necrosis factor (TNF)-alpha in endothelial… 
2004
2004
Mechanisms of mitogen-activated protein kinase inhibition by parathyroid hormone in osteoblast-like cells.
Parathyroid hormone (PTH) dose dependently inhibits growth factor- and stress-induced osteoblast proliferation via inactivating… 
Highly Cited
2001
Highly Cited
2001
Role of extracellular signal‐regulated protein kinase cascade in macrophage killing of Candida albicans
The pathogenic yeast Candida albicans and its derivedmolecules stimulate a wide range of macrophage secretory functions andmay… 
1999
1999
H‐2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1
We have used a number of in vitro and in vivo techniques to identify the molecules that can bind to the cytoplasmic tail of the… 
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