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Dual Specificity Phosphatase 1

Known as: MKP-1 Phosphatase, Map Kinase Phosphatase 1, 3CH134 Phosphatase 
A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It… Expand
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Protein Ser/Thr phosphatase-1 (PP1) catalyzes the majority of eukaryotic protein dephosphorylation reactions in a highly… Expand
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Highly Cited
2007
Highly Cited
2007
Mitogen-activated protein kinase (MAPK) and PUF (for Pumilio and FBF [fem-3 binding factor]) RNA-binding proteins control many… Expand
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Highly Cited
2006
Highly Cited
2006
Activation of the mitogen-activated protein kinase (MAPK) cascade after Toll-like receptor stimulation enables innate immune… Expand
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Highly Cited
2006
Highly Cited
2006
TLR-induced innate immunity and inflammation are mediated by signaling cascades leading to activation of the MAPK family of Ser… Expand
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Highly Cited
2004
Highly Cited
2004
The p38 and JNK classes of mitogen-activated protein kinases (MAPKs) have evolutionarily conserved roles in the control of… Expand
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Highly Cited
2004
Highly Cited
2004
Mitogen‐activated protein kinases (MAPKs) are integral to the mechanisms by which cells respond to physiological stimuli and to a… Expand
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Highly Cited
2000
Highly Cited
2000
Our laboratory has recently demonstrated a role for the phosphatidylinositol 3-kinase-mediated inducible NO synthase (iNOS… Expand
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Highly Cited
1999
Highly Cited
1999
Pathophysiological hypoxia is an important modulator of gene expression in solid tumors and other pathologic conditions. We… Expand
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Highly Cited
1999
Highly Cited
1999
The crystal structure of the catalytic domain from the MAPK phosphatase Pyst1 (Pyst1–CD) has been determined at 2.35 Å. The… Expand
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Highly Cited
1998
Highly Cited
1998
Previously we showed that rat mesangial cells are normally resistant to tumor necrosis factor-α (TNF-α)-induced apoptosis. They… Expand
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