D. Leung

Publications1,002
h-index126
Citations55,649
Highly Influential Citations1,185
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Endogenous antimicrobial peptides and skin infections in atopic dermatitis.
TLDR
A deficiency in the expression of antimicrobial peptides may account for the susceptibility of patients with atopic dermatitis to skin infection with S. aureus.
Genome sequence of a serotype M3 strain of group A Streptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence
TLDR
The results show that phage-mediated recombination has played a critical role in the emergence of a new, unusually virulent clone of serotype M3 GAS.
Filaggrin mutations associated with skin and allergic diseases.
TLDR
The biology of this molecule and the role of mutations in its altered function offer new insights into a range of conditions not previously thought to be related to one another.
New insights into atopic dermatitis.
TLDR
This review summarizes recent progress in the understanding of the pathophysiology of atopic dermatitis and the implications for new management strategies.
Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1
TLDR
The upregulation of MKP-1 by vitamin D is identified as a novel pathway by which vitamin D inhibits LPS-induced p38 activation and cytokine production in monocytes/macrophages.
Superantigens and their potential role in human disease.
TLDR
The role of superantigens in certain human diseases such as toxic shock syndrome, some autoimmune diseases like Kawasaki syndrome, and perhaps some immunodeficiency disease such as that secondary to HIV infection is being addressed and mechanisms are being defined.
Atopic dermatitis: a disease of altered skin barrier and immune dysregulation
TLDR
New insights into the genetics and pathophysiology of AD point to an important role of structural abnormalities in the epidermis as well as immune dysregulation not only for this skin disease but also for the development of asthma and allergies.
Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus…
TLDR
The consensus report is endorsed by both academies and aims to serve as a guideline for clinical practice in Europe as well as in North America.
Atopic dermatitis: new insights and opportunities for therapeutic intervention.
  • D. Leung
  • Medicine
    The Journal of allergy and clinical immunology
  • 1 May 2000
TLDR
This review will examine the cellular and molecular mechanisms that contribute to AD as well as the immunologic triggers involved in its pathogenesis to provide new opportunities for therapeutic intervention in this common skin condition.
Cytokine modulation of atopic dermatitis filaggrin skin expression.
TLDR
Patients with AD have an acquired defect in filaggrin expression that can be modulated by the atopic inflammatory response, and neutralization of IL-4 and IL-13 could improve skin barrier integrity.
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