Endogenous antimicrobial peptides and skin infections in atopic dermatitis.
A deficiency in the expression of antimicrobial peptides may account for the susceptibility of patients with atopic dermatitis to skin infection with S. aureus.
Filaggrin mutations associated with skin and allergic diseases.
The biology of this molecule and the role of mutations in its altered function offer new insights into a range of conditions not previously thought to be related to one another.
Genome sequence of a serotype M3 strain of group A Streptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence
- S. Beres, Gail L Sylva, J. Musser
- BiologyProceedings of the National Academy of Sciences…
- 16 July 2002
The results show that phage-mediated recombination has played a critical role in the emergence of a new, unusually virulent clone of serotype M3 GAS.
New insights into atopic dermatitis.
- D. Leung, M. Boguniewicz, M. Howell, I. Nomura, Q. Hamid
- Medicine, BiologyJournal of Clinical Investigation
- 1 March 2004
This review summarizes recent progress in the understanding of the pathophysiology of atopic dermatitis and the implications for new management strategies.
Atopic dermatitis: a disease of altered skin barrier and immune dysregulation
New insights into the genetics and pathophysiology of AD point to an important role of structural abnormalities in the epidermis as well as immune dysregulation not only for this skin disease but also for the development of asthma and allergies.
Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1
The upregulation of MKP-1 by vitamin D is identified as a novel pathway by which vitamin D inhibits LPS-induced p38 activation and cytokine production in monocytes/macrophages.
Superantigens and their potential role in human disease.
Cytokine modulation of atopic dermatitis filaggrin skin expression.
Staphylococcal and Streptococcal Superantigen Exotoxins
- A. R. Spaulding, Wilmara Salgado-Pabón, Petra L. Kohler, A. Horswill, D. Leung, P. Schlievert
- Medicine, BiologyClinical Microbiology Reviews
- 1 July 2013
The review discusses the major known and possible human disease associations with superantigens, including associations with toxic shock syndromes, atopic dermatitis, pneumonia, infective endocarditis, and autoimmune sequelae to streptococcal illnesses.