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DRD4 gene

Known as: D4DR, DOPAMINE RECEPTOR D4, DRD4 
This gene plays a role in G protein-coupled receptor signal transduction and inhibits adenylyl cyclase activity.
National Institutes of Health

Related topics

Related topics

7 relations
DRD4 protein, humanG Protein-Coupled Receptor SignalingLigand BindingReceptor Signaling

Papers overview

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2010
2010
The DRD4 receptor Exon 3 VNTR and 5′ SNP variants and mRNA expression in human post‐mortem brain tissue
Genetic variation within the dopamine D4 receptor (DRD4) gene has been implicated in many neuropsychiatric disorders and… 
Highly Cited
2005
Highly Cited
2005
CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents
Objectives Smoking is a major cause of death and often initiates in adolescence. Mutations in CYP2A6 slow metabolism of nicotine… 
Highly Cited
2004
Highly Cited
2004
Multiple marker analysis at the promoter region of the DRD4 gene and ADHD: Evidence of linkage and association with the SNP −616
Abnormalities of dopamine neurotransmission have been hypothesized to play an important role in the pathophysiology of attention… 
2003
2003
DRD4 exon III polymorphism and response to risperidone in Israeli adolescents with schizophrenia: a pilot pharmacogenetic study
Highly Cited
2002
Highly Cited
2002
Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders.
Variants of the functional polymorphism in the serotonin transporter (upstream regulatory region: 5-HTTLPR), the tryptophan… 
2000
2000
Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects.
Heroin abuse is a major social and public health problem in many parts of the world, yet relatively little is known about its… 
Highly Cited
1999
Highly Cited
1999
Association analysis between dopamine receptor genes and bipolar affective disorder
Highly Cited
1998
Highly Cited
1998
Association between dopamine receptor genes and migraine without aura in a Sardinian sample
Background: Migraine seems to be caused by a combination of environmental and genetic factors. Clinical and pharmacologic… 
Highly Cited
1997
Highly Cited
1997
Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects.
This study was designed to assess the association between novelty seeking and D4DR gene polymorphism in the Japanese population… 
Highly Cited
1995
Highly Cited
1995
DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls.
The DRD4 dopamine receptor is thus far unique among neurotransmitter receptors in having a highly polymorphic gene structure that… 
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