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DNM2 protein, human

Known as: Dynamin-2, EC 3.6.5.5, dynamin 2, human 
Dynamin-2 (870 aa, ~98 kDa) is encoded by the human DNM2 gene. This protein plays a role in both microtubule polymerization and GTP hydrolysis.
National Institutes of Health

Related topics

Related topics

19 relations
Cell Cycle ProgressionCytoskeletal ModelingCytoskeletonDNM2 gene

Broader (2)

Dynamin 2Dynamin GTPase

Papers overview

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Highly Cited
2015
Highly Cited
2015
Hepatitis E Virus Enters Liver Cells Through a Dynamin‐2, Clathrin and Membrane Cholesterol‐Dependent Pathway
The hepatitis E virus (HEV) causes large outbreaks and sporadic cases of acute viral hepatitis in developing countries. In the… 
Highly Cited
2011
Highly Cited
2011
Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway
Influenza A virus (IAV) enters host cells upon binding of its hemagglutinin glycoprotein to sialylated host cell receptors… 
Highly Cited
2010
Highly Cited
2010
Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy
Highly Cited
2008
Highly Cited
2008
Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated by dynamin-2
The LOX-1 scavenger receptor recognises pro-atherogenic oxidised low-density lipoprotein (OxLDL) particles and is implicated in… 
Highly Cited
2007
Highly Cited
2007
Two novel mutations in dynamin-2 cause axonal Charcot–Marie–Tooth disease
Background: Recently, mutations affecting different domains of dynamin-2 (DNM2) were associated alternatively with autosomal… 
Review
2006
Review
2006
Caveolae Internalization Regulates Integrin-Dependent Signaling Pathways
Integrin-mediated adhesion regulates trafficking of cholesterol-enriched membrane microdomains (CEMM). Upon cell detachment from… 
Highly Cited
2005
Highly Cited
2005
Regulatory role of dynamin‐2 in VEGFR‐2/KDR‐mediated endothelial signaling
Vascular endothelial growth factor receptor‐2 (VEGFR‐2, also known as KDR) is a receptor tyrosine kinase (RTK) regulating… 
Highly Cited
2001
Highly Cited
2001
Beta-arrestin- and dynamin-dependent endocytosis of the AT1 angiotensin receptor.
The major mechanism of agonist-induced internalization of G protein-coupled receptors (GPCRs) is beta-arrestin- and dynamin… 
Highly Cited
2000
Highly Cited
2000
Evidence That Dynamin-2 Functions as a Signal-Transducing Gtpase
The role of dynamin GTPases in the regulation of receptor-mediated endocytosis is well established. Here, we present new evidence… 
Highly Cited
1995
Highly Cited
1995
Dynamin GTPase is stimulated by crosslinking through the C‐terminal proline‐rich domain.
Dynamin is a 100 kDa GTPase required for endocytic‐coated vesicle formation. Recombinant human neuronal dynamin (dynamin‐1) was… 
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