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Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II.
TLDR
The recognition of Ang II's pathogenic actions is leading to novel clinical applications of angiotensin-converting enzyme inhibitors and AT1R antagonists, in addition to their established therapeutic actions in essential hypertension. Expand
Control of aldosterone secretion: a model for convergence in cellular signaling pathways.
Aldosterone secretion by glomerulosa cells is stimulated by angiotensin II (ANG II), extracellular K(+), corticotrophin, and several paracrine factors. Electrophysiological, fluorimetric, andExpand
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
TLDR
These findings imply the existence of independent G protein- and beta-arrestin 2-mediated pathways leading to ERK1/2 activation and theexistence of distinct "active" conformations of a seven-membrane-spanning receptor coupled to each. Expand
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
TLDR
These findings imply the existence of independent G protein- and β-arrestin 2-mediated pathways leading to ERK1/2 activation and theexistence of distinct “active” conformations of a seven-membrane-spanning receptor coupled to each. Expand
Visualization and Manipulation of Plasma Membrane-Endoplasmic Reticulum Contact Sites Indicates the Presence of Additional Molecular Components within the STIM1-Orai1 Complex*♦
TLDR
These studies are the first to detect juxtaposed areas between the ER and the plasma membrane in live cells, revealing novel details of STIM1-Orai1 interactions. Expand
STIM and Orai: the long-awaited constituents of store-operated calcium entry.
TLDR
Recent developments in the area of Ca(2+) signaling are summarized, which includes landmark discoveries in clarifying how these proteins work in concert and what developmental and cellular processes require their participation most. Expand
Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor
TLDR
Data indicate that internalized AT1 receptors are processed via vesicles that resemble multivesicular bodies, and recycle to the cell surface by a rapid PI 3-kinase–dependent recycling route, as well as by a slower pathway that is less sensitive to PI 3,kinase inhibitors. Expand
Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners
TLDR
The data suggest that interaction with and sequestration of PIP3 may not be the sole mechanism by which PH domains interfere with cellular responses and that their interaction with other membrane components, most probably with proteins, allows a more specific participation in the regulation of specific signaling pathways. Expand
Signal transduction of the CB1 cannabinoid receptor.
TLDR
Evidence exists that CB(1)Rs can also stimulate adenylyl cyclase via G, induce receptor-mediated Ca(2+) fluxes and stimulate phospholipases in some experimental models, and the altered pharmacological properties of these receptor complexes may explain the pharmacological differences observed in various tissues. Expand
Mechanisms and functions of AT1 angiotensin receptor internalization
TLDR
There is increasing evidence for a role of internalization in sustained signal generation from the AT(1) receptor, including its precise mode and route of endocytosis, and the potential roles of cytoplasmic and nuclear receptors. Expand
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