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DNM2 gene

Known as: DI-CMTB, CMTDI1, CMT2M 
This gene plays a role in both GTP hydrolysis and microtubule organization.
National Institutes of Health

Related topics

Related topics

11 relations
CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder)Cell Cycle ProgressionCytoskeletal ModelingCytoskeletal Proteins

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DNM2 wt Allele

Papers overview

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Highly Cited
2013
Highly Cited
2013
Lipid droplet breakdown requires Dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes
Dynamin 2 is required for starvation-mediated breakdown of lipid droplets in hepatocytes by promoting vesiculation of… 
Highly Cited
2011
Highly Cited
2011
Defects in amphiphysin 2 (BIN1) and triads in several forms of centronuclear myopathies
Myotubular myopathy and centronuclear myopathies (CNM) are congenital myopathies characterized by generalized muscle weakness and… 
Review
2010
Review
2010
Dynamin 2 and human diseases
Dynamin 2 (DNM2) mutations cause autosomal dominant centronuclear myopathy, a rare form of congenital myopathy, and intermediate… 
Highly Cited
2007
Highly Cited
2007
Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef
Nef is a virulence factor of HIV-1 and other primate lentiviruses that is crucial for rapid progression to AIDS. In cell culture… 
Highly Cited
2006
Highly Cited
2006
Characterization of the muscle involvement in dynamin 2-related centronuclear myopathy.
Centronuclear myopathy (CNM) is a slowly progressive congenital myopathy characterized by abnormal centrally located nuclei in a… 
Review
2006
Review
2006
Schwann cells and the pathogenesis of inherited motor and sensory neuropathies (Charcot‐Marie‐Tooth disease)
Over the last 15 years, a number of mutations in a variety of genes have been identified that lead to inherited motor and sensory… 
Highly Cited
2006
Highly Cited
2006
A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.
In eukaryotic cells, phosphoinositides are lipid second messengers important for many cellular processes and have been found… 
Highly Cited
2005
Highly Cited
2005
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse
Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune… 
Highly Cited
1994
Highly Cited
1994
Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues.
Dynamin is a 100-kDa microtubule-activated GTPase originally isolated from mammalian brain that has been proposed to be crucial… 
Highly Cited
1991
Highly Cited
1991
Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
We have isolated a cDNA encoding a third type of protein-tyrosine-phosphatase. We screened human megakaryoblastic cell line (MEG… 
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