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KCNQ1 gain-of-function mutation in familial atrial fibrillation.
Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly understood. We studied a family with hereditary persistent AF and identified the causative mutation (S140G)Expand
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Transcription factor ISL1 is essential for pacemaker development and function.
The sinoatrial node (SAN) maintains a rhythmic heartbeat; therefore, a better understanding of factors that drive SAN development and function is crucial to generation of potential therapies, such asExpand
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A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect
GATA6 is a member of the GATA family of transcription factors, and its expression and functions overlap with those of GATA4 during heart development. Mutations in GATA4 have been related to humanExpand
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MicroRNA expression signature in atrial fibrillation with mitral stenosis.
The aim of this study was to investigate the microRNA (miRNA) signature in atrial fibrillation (AF) with mitral stenosis (MS). miRNA arrays were used to evaluate the expression signature of the rightExpand
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Identification of a Kir3.4 mutation in congenital long QT syndrome.
Congenital long QT syndrome (LQTS) is a hereditary disorder that leads to sudden cardiac death secondary to fatal cardiac arrhythmias. Although many genes for LQTS have been described, the etiologyExpand
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MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism
BackgroundAcute pulmonary embolism (APE) remains a diagnostic challenge due to a variable clinical presentation and the lack of a reliable screening tool. MicroRNAs (miRNAs) regulate gene expressionExpand
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miRNA-940 reduction contributes to human Tetralogy of Fallot development
Tetralogy of Fallot (TOF) is a complex congenital heart defect and the microRNAs regulation in TOF development is largely unknown. Herein, we explored the role of miRNAs in TOF. Among 75 dysregulatedExpand
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Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation
Accumulating evidence reveals that genetic variants play pivotal roles in familial atrial fibrillation (AF). However, the molecular defects in most patients with AF remain to be identified. Here, weExpand
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β2‐ but not β1‐adrenoceptor activation modulates intracellular oxygen availability
β‐Adrenoceptors (β‐ARs) play a critical role in the regulation of cardiovascular function. Intracellular oxygen homeostasis is crucial for the survival of cardiomyocytes. However, it is still unclearExpand
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The genetics of atrial fibrillation: from the bench to the bedside.
Atrial fibrillation (AF) has become a growing global epidemic and a financial burden for society. The past 10 years have seen significant advances in our understanding of the genetic aspects of AF:Expand
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