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DNA damage checkpoint

A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle… 
National Institutes of Health

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mitotic DNA damage checkpoint

Papers overview

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2016
2016
The KYxxL motif in Rad17 protein is essential for the interaction with the 9-1-1 complex.
Highly Cited
2015
Highly Cited
2015
Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling
Significance Chromosomal double-strand breaks (DSBs) are cytotoxic forms of DNA damage that must be accurately repaired to… 
2013
2013
Direct and Indirect Control of the Initiation of Meiotic Recombination by DNA Damage Checkpoint Mechanisms in Budding Yeast
Meiotic recombination plays an essential role in the proper segregation of chromosomes at meiosis I in many sexually reproducing… 
2010
2010
NEK11−Linking CHK1 and CDC25A in DNA damage checkpoint signaling
The DNA damage induced G2/M checkpoint is an important guardian of the genome that prevents cell division when DNA lesions are… 
2007
2007
Undamaged DNA Transmits and Enhances DNA Damage Checkpoint Signals in Early Embryos
ABSTRACT In Xenopus laevis embryos, the midblastula transition (MBT) at the 12th cell division marks initiation of critical… 
2006
2006
Mutator Phenotype of Caenorhabditis elegans DNA Damage Checkpoint Mutants
DNA damage response proteins identify sites of DNA damage and signal to downstream effectors that orchestrate either apoptosis or… 
2006
2006
A conserved RAS/mitogen-activated protein kinase pathway regulates DNA damage-induced cell death postirradiation in Radelegans.
Although the epidermal growth factor receptor (EGFR) signaling pathway is overactive in more than half of human cancers and… 
2005
2005
Cooperative Control of Crb2 by ATM Family and Cdc2 Kinases Is Essential for the DNA Damage Checkpoint in Fission Yeast
ABSTRACT The cellular responses to double-stranded breaks (DSBs) typically involve the extensive accumulation of checkpoint… 
Highly Cited
2003
Highly Cited
2003
Critical Role for Mouse Hus1 in an S-Phase DNA Damage Cell Cycle Checkpoint
ABSTRACT Mouse Hus1 encodes an evolutionarily conserved DNA damage response protein. In this study we examined how targeted… 
1998
1998
Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast
Abstract A checkpoint responding to DNA damage in G2 results in a delay in the onset of mitosis through inhibition of p34cdc2… 
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