DNA damage checkpoint

A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Understanding the role of DNA damage checkpoint kinases in the cellular response to genotoxic stress requires the knowledge of… (More)
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Highly Cited
2006
Highly Cited
2006
Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit the progression of preneoplastic… (More)
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Highly Cited
2005
Highly Cited
2005
DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but the selective pressure for their… (More)
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Highly Cited
2004
Highly Cited
2004
A single double-strand break (DSB) induced by HO endonuclease triggers both repair by homologous recombination and activation of… (More)
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Highly Cited
2003
Highly Cited
2003
We have analyzed how single-strand DNA gaps affect DNA replication in Xenopus egg extracts. DNA lesions generated by etoposide, a… (More)
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Highly Cited
2002
Highly Cited
2002
53BP1 binds to the tumor suppressor protein p53 and has a potential role in DNA damage responses. We used small interfering RNA… (More)
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Highly Cited
2000
Highly Cited
2000
Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle checkpoint control in lower eukaryotes. By… (More)
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Highly Cited
2000
Highly Cited
2000
Chk2/hcds1, the human homolog of the Saccharomyces cerevisiae RAD53/SPK1 and Schizosaccharomyces pombe cds1 DNA damage checkpoint… (More)
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Highly Cited
1997
Highly Cited
1997
Arrest of the cell cycle at the G2 checkpoint, induced by DNA damage, requires inhibitory phosphorylation of the kinase Cdc2 in… (More)
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Highly Cited
1997
Highly Cited
1997
A single double-stranded DNA (dsDNA) break will cause yeast cells to arrest in G2/M at the DNA damage checkpoint. If the dsDNA… (More)
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