The KYxxL motif in Rad17 protein is essential for the interaction with the 9-1-1 complex.

Abstract

ATR-dependent DNA damage checkpoint is the major DNA damage checkpoint against UV irradiation and DNA replication stress. The Rad17-RFC and Rad9-Rad1-Hus1 (9-1-1) complexes interact with each other to contribute to ATR signaling, however, the precise regulatory mechanism of the interaction has not been established. Here, we identified a conserved sequence… (More)
DOI: 10.1016/j.bbrc.2016.07.014

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@article{Fukumoto2016TheKM, title={The KYxxL motif in Rad17 protein is essential for the interaction with the 9-1-1 complex.}, author={Yasunori Fukumoto and Masayoshi Ikeuchi and Yuji Nakayama and Naoto Yamaguchi}, journal={Biochemical and biophysical research communications}, year={2016}, volume={477 4}, pages={982-987} }